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    trm8 tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539574, updated on 13-Mar-2024

    Summary

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    Gene symbol
    trm8
    Gene description
    tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8
    Primary source
    PomBase:SPCPB16A4.04c
    Locus tag
    SPCPB16A4.04c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See trm8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003421.2 (950726..952502, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamideformyltransferase Neighboring gene miscRNA Neighboring gene putative urease accessory protein UREG Neighboring gene miscRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences. De Zoysa T, et al. PLoS Genet, 2020 Aug. PMID 32841241, Free PMC Article
    2. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
    3. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
    4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
      Title: Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of tRNA (m7G46) methyltransferase complex IC
    Inferred by Curator
    more info
    		  
    part_of tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8
    NP_588028.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      950726..952502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023019.2 → NP_588028.1  tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588028.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q96WV1
      Conserved Domains (2) summary
      COG0220
      Location:31 → 272
      TrmB; tRNA G46 methylase TrmB [Translation, ribosomal structure and biogenesis]
      pfam02390
      Location:80 → 264
      Methyltransf_4; Putative methyltransferase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials