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    Cdk11b cyclin-dependent kinase 11B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252879, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdk11bprovided by RGD
    Official Full Name
    cyclin-dependent kinase 11Bprovided by RGD
    Primary source
    RGD:628604
    See related
    Ensembl:ENSRNOG00000017213 AllianceGenome:RGD:628604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdk11; Cdc2l1
    Summary
    Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of cell growth; and regulation of mRNA processing. Predicted to act upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Predicted to be located in nuclear membrane and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 80.7), Spleen (RPKM 77.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171495042..171521143)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166212761..166238883)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173051900..173078049)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487048 Neighboring gene solute carrier family 35, member E2B Neighboring gene ribosomal protein L27A like 10 Neighboring gene matrix metallopeptidase 23 Neighboring gene MIB E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells. Kerr M, et al. Biochim Biophys Acta, 1994 Aug 2. PMID 8049264
    2. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Liu X, et al. Cell Mol Neurobiol, 2013 Aug. PMID 23703121
    3. Protein expression pattern of CDK11(p58) during testicular development in the mouse. Niu Z, et al. Mol Cell Biochem, 2005 Feb. PMID 15792358
    4. Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Li T, et al. Mol Cell Biol, 2004 Apr. PMID 15060143, Free PMC Article
    5. The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide. Liu X, et al. Inflammation, 2012 Aug. PMID 22527143

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AKT signaling pathway is involved in CDK11(p58)-induced neuronal apoptosis process.
      Title: LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway.
    2. These findings indicated that the functional interaction between CDK11(p58) and beta-1,4-GalT-I may play an important role during astrocyte activation after LPS administration.
      Title: The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 11B
    Names
    PITSLRE serine/threonine-protein kinase CDC2L1
    cell division cycle 2 homolog-like 1
    cell division cycle 2-like protein kinase 1
    cell division protein kinase 11
    cyclin-dependent kinase 11
    galactosyltransferase-associated protein kinase p58/GTA
    NP_665709.2
    XP_006239591.1
    XP_006239592.1
    XP_006239593.1
    XP_038965218.1
    XP_038965221.1
    XP_038965222.1
    XP_038965223.1
    XP_063143248.1
    XP_063143249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145766.2 → NP_665709.2  cyclin-dependent kinase 11B

      See identical proteins and their annotated locations for NP_665709.2

      Status: VALIDATED

      Source sequence(s)
      AA817907, DY544650, DY556124, EX490221, FM031851, FM044847
      UniProtKB/TrEMBL
      D4A3G2
      Related
      ENSRNOP00000023274.6, ENSRNOT00000023274.7
      Conserved Domains (1) summary
      cd07843
      Location:421 → 712
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171495042..171521143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239531.5 → XP_006239593.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006239593.1

      UniProtKB/TrEMBL
      D3ZML3
      Related
      ENSRNOP00000039105.5
      Conserved Domains (2) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390 → 680
      PLN00009; cyclin-dependent kinase A; Provisional

    2. XM_063287179.1 → XP_063143249.1  cyclin-dependent kinase 11B isoform X4

    3. XM_006239530.4 → XP_006239592.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006239592.1

      UniProtKB/TrEMBL
      D3ZML3
      Conserved Domains (2) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390 → 680
      PLN00009; cyclin-dependent kinase A; Provisional

    4. XM_063287178.1 → XP_063143248.1  cyclin-dependent kinase 11B isoform X1

    5. XM_039109290.2 → XP_038965218.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/TrEMBL
      A6IUR2
      Conserved Domains (1) summary
      cd07843
      Location:420 → 711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    6. XM_006239529.5 → XP_006239591.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006239591.1

      UniProtKB/TrEMBL
      D3ZML3
      Conserved Domains (2) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390 → 680
      PLN00009; cyclin-dependent kinase A; Provisional

    7. XM_039109294.2 → XP_038965222.1  cyclin-dependent kinase 11B isoform X6

      Conserved Domains (1) summary
      cd07843
      Location:204 → 495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    8. XM_039109293.2 → XP_038965221.1  cyclin-dependent kinase 11B isoform X5

      Conserved Domains (1) summary
      cd07843
      Location:225 → 516
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    9. XM_039109295.2 → XP_038965223.1  cyclin-dependent kinase 11B isoform X7

      UniProtKB/Swiss-Prot
      P46892
      Conserved Domains (1) summary
      cd07843
      Location:76 → 367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46892.1 GenPept UniProtKB/Swiss-Prot:P46892

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