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    Lalba lactalbumin, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24528, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Lalbaprovided by RGD
    Official Full Name
    lactalbumin, alphaprovided by RGD
    Primary source
    RGD:2987
    See related
    Ensembl:ENSRNOG00000010811 AllianceGenome:RGD:2987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and lactose synthase activity. Predicted to be involved in lactose biosynthetic process. Predicted to be located in extracellular region. Orthologous to human LALBA (lactalbumin alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 5.1), Testes (RPKM 4.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131504572..131520707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129625531..129628034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140088420..140096347, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479784 Neighboring gene olfactory receptor family 5 subfamily BS member 2, pseudogene 1 Neighboring gene olfactory receptor pseudogene 1110 Neighboring gene olfactory receptor family 11 subfamily M member 3 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene KAT8 regulatory NSL complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bovine milk-derived α-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sodium sulfate-treated mice. Yamaguchi M, et al. Biosci Biotechnol Biochem, 2014. PMID 25036966
    2. Amino acid sequence of rat alpha-lactalbumin: a unique alpha-lactalbumin. Prasad RV, et al. Biochemistry, 1982 Mar 30. PMID 7044414
    3. Similarity of the nucleotide sequences of rat alpha-lactalbumin and chicken lysozyme genes. Qasba PK, et al. Nature, 1984 Mar 22-28. PMID 6709045
    4. Rat alpha-lactalbumin has a 17-residue-long COOH-terminal hydrophobic extension as judged by sequence analysis of the cDNA clones. Dandekar AM, et al. Proc Natl Acad Sci U S A, 1981 Aug. PMID 6272279, Free PMC Article
    5. Increased protein absorption after acute gastroenteritis in children. Holm S, et al. Acta Paediatr, 1992 Aug. PMID 1327323

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mammary tissue from late pregnant Restricted rats had elevated alpha-lactalbumin, but not beta-casein mRNA.
      Title: Uteroplacental insufficiency alters the mammary gland response to lactogenic hormones in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactose synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactose synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-lactalbumin
    Names
    lactose synthase B protein
    NP_036726.1
    XP_063119053.1
    XP_063119054.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012594.2 → NP_036726.1  alpha-lactalbumin precursor

      See identical proteins and their annotated locations for NP_036726.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007, V01251
      UniProtKB/Swiss-Prot
      P00714, P00715
      Related
      ENSRNOP00000014457.1, ENSRNOT00000014456.4
      Conserved Domains (1) summary
      pfam00062
      Location:20 → 137
      Lys; C-type lysozyme/alpha-lactalbumin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131504572..131520707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262984.1 → XP_063119054.1  alpha-lactalbumin isoform X1

      UniProtKB/TrEMBL
      F1M7M1

    2. XM_063262983.1 → XP_063119053.1  alpha-lactalbumin isoform X1

      UniProtKB/TrEMBL
      F1M7M1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00714.1 GenPept UniProtKB/Swiss-Prot:P00714

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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