U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Zfp189 zinc finger protein 189 [ Mus musculus (house mouse) ]

    Gene ID: 230162, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zfp189provided by MGI
    Official Full Name
    zinc finger protein 189provided by MGI
    Primary source
    MGI:MGI:2444707
    See related
    Ensembl:ENSMUSG00000039634 AllianceGenome:MGI:2444707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C430015I23Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain and eye. Orthologous to human ZNF189 (zinc finger protein 189). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.7), CNS E14 (RPKM 2.5) and 25 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zfp189 in Genome Data Viewer
    Location:
    4 B1; 4 26.55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49521176..49531558)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49521176..49531558)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52736 Neighboring gene mitochondrial ribosomal protein L50 Neighboring gene aldolase B, fructose-bisphosphate Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene predicted gene, 33106

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis. Xia Z, et al. Autoimmunity, 2023 Dec. PMID 36942486
    2. CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use. Teague CD, et al. Biol Psychiatry, 2023 Mar 15. PMID 36253194, Free PMC Article
    3. Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex. Lorsch ZS, et al. Nat Neurosci, 2019 Sep. PMID 31427770, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.
      Title: Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.
    2. CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
      Title: CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
    3. Zfp189 in prefrontal cortical neurons...promotes behavioral resilience
      Title: Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 189

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289901.1 → NP_001276830.1  zinc finger protein 189

      See identical proteins and their annotated locations for NP_001276830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049475, AK051265, BY085925, BY420591
      Consensus CDS
      CCDS18175.1
      UniProtKB/TrEMBL
      Q8BKP2
      Related
      ENSMUSP00000036663.7, ENSMUST00000042964.13
      Conserved Domains (4) summary
      cd07765
      Location:12 → 39
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:116 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    2. NM_145547.3 → NP_663522.2  zinc finger protein 189

      See identical proteins and their annotated locations for NP_663522.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049475, AK051265, BY085925, BY420591
      Consensus CDS
      CCDS18175.1
      UniProtKB/TrEMBL
      Q8BKP2
      Related
      ENSMUSP00000103324.2, ENSMUST00000107696.2
      Conserved Domains (4) summary
      cd07765
      Location:12 → 39
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:116 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      49521176..49531558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous