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    Kat7 K(lysine) acetyltransferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 217127, updated on 10-Oct-2019

    Summary

    Official Symbol
    Kat7provided by MGI
    Official Full Name
    K(lysine) acetyltransferase 7provided by MGI
    Primary source
    MGI:MGI:2182799
    See related
    Ensembl:ENSMUSG00000038909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbo1; Hboa; Myst2
    Expression
    Ubiquitous expression in testis adult (RPKM 20.1), placenta adult (RPKM 13.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Kat7 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95271853..95310246, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (95135573..95171515, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11515 Neighboring gene tachykinin 4 Neighboring gene predicted gene 11520 Neighboring gene family with sequence similarity 117, member A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC56758

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to actinomycin D ISO
    Inferred from Sequence Orthology
    more info
     
    response to anisomycin ISO
    Inferred from Sequence Orthology
    more info
     
    response to dithiothreitol ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    response to sorbitol ISO
    Inferred from Sequence Orthology
    more info
     
    stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT7
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
    MYST histone acetyltransferase 2
    histone acetyltransferase MYST2
    histone acetyltransferase binding to ORC1
    lysine acetyltransferase 7
    NP_001181932.1
    NP_001181933.1
    NP_808287.1
    XP_006533076.1
    XP_006533077.1
    XP_006533078.1
    XP_006533079.1
    XP_006533081.1
    XP_030101718.1
    XP_030101719.1
    XP_030101720.1
    XP_030101721.1
    XP_030101722.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195003.1NP_001181932.1  histone acetyltransferase KAT7 isoform 1

      See identical proteins and their annotated locations for NP_001181932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK147968, AL627222, CD555481
      Consensus CDS
      CCDS56799.1
      UniProtKB/TrEMBL
      Q1AJD0, Q3UGF2
      Related
      ENSMUSP00000103362.3, ENSMUST00000107734.9
      Conserved Domains (3) summary
      PLN00104
      Location:324609
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam05109
      Location:27197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01530
      Location:184212
      zf-C2HC; Zinc finger, C2HC type
    2. NM_001195004.1NP_001181933.1  histone acetyltransferase KAT7 isoform 2

      See identical proteins and their annotated locations for NP_001181933.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL627222, BC057102, CD555481
      Consensus CDS
      CCDS56798.1
      UniProtKB/Swiss-Prot
      Q5SVQ0
      UniProtKB/TrEMBL
      Q3TD41
      Related
      ENSMUSP00000103361.3, ENSMUST00000107733.9
      Conserved Domains (4) summary
      PLN00104
      Location:294579
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam05109
      Location:27197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd16378
      Location:209262
      CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
      pfam01530
      Location:184212
      zf-C2HC; Zinc finger, C2HC type
    3. NM_177619.3NP_808287.1  histone acetyltransferase KAT7 isoform 3

      See identical proteins and their annotated locations for NP_808287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL627222
      Consensus CDS
      CCDS25275.1
      UniProtKB/Swiss-Prot
      Q5SVQ0
      Related
      ENSMUSP00000099448.3, ENSMUST00000103159.9
      Conserved Domains (2) summary
      pfam01530
      Location:125153
      zf-C2HC; Zinc finger, C2HC type
      cl27485
      Location:235520
      MOZ_SAS; MOZ/SAS family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

      Range
      95271853..95310246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533018.4XP_006533081.1  histone acetyltransferase KAT7 isoform X7

      See identical proteins and their annotated locations for XP_006533081.1

      UniProtKB/TrEMBL
      Q3UGU8
      Conserved Domains (2) summary
      PLN00104
      Location:168453
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam01530
      Location:2856
      zf-C2HC; Zinc finger, C2HC type
    2. XM_006533013.4XP_006533076.1  histone acetyltransferase KAT7 isoform X1

      See identical proteins and their annotated locations for XP_006533076.1

      UniProtKB/Swiss-Prot
      Q5SVQ0
      Related
      ENSMUSP00000090441.5, ENSMUST00000092766.11
      Conserved Domains (3) summary
      pfam01530
      Location:186212
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:395573
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:331609
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    3. XM_006533014.4XP_006533077.1  histone acetyltransferase KAT7 isoform X2

      UniProtKB/Swiss-Prot
      Q5SVQ0
      Related
      ENSMUSP00000072416.5, ENSMUST00000072621.11
      Conserved Domains (3) summary
      pfam01530
      Location:186212
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:365543
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:301579
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    4. XM_030245861.1XP_030101721.1  histone acetyltransferase KAT7 isoform X8

    5. XM_006533016.1XP_006533079.1  histone acetyltransferase KAT7 isoform X7

      See identical proteins and their annotated locations for XP_006533079.1

      UniProtKB/TrEMBL
      Q3UGU8
      Conserved Domains (2) summary
      PLN00104
      Location:168453
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam01530
      Location:2856
      zf-C2HC; Zinc finger, C2HC type
    6. XM_030245860.1XP_030101720.1  histone acetyltransferase KAT7 isoform X6

    7. XM_030245858.1XP_030101718.1  histone acetyltransferase KAT7 isoform X4

    8. XM_006533015.4XP_006533078.1  histone acetyltransferase KAT7 isoform X3

      Conserved Domains (2) summary
      pfam01530
      Location:186212
      zf-C2HC; Zinc finger, C2HC type
      cl17182
      Location:331544
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    9. XM_030245859.1XP_030101719.1  histone acetyltransferase KAT7 isoform X5

    10. XM_030245862.1XP_030101722.1  histone acetyltransferase KAT7 isoform X9

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