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    APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A [ Homo sapiens (human) ]

    Gene ID: 200315, updated on 11-Apr-2024

    Summary

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    Official Symbol
    APOBEC3Aprovided by HGNC
    Official Full Name
    apolipoprotein B mRNA editing enzyme catalytic subunit 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:17343
    See related
    Ensembl:ENSG00000128383 MIM:607109; AllianceGenome:HGNC:17343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A3A; ARP3; PHRBN; bK150C2.1
    Summary
    This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in bone marrow (RPKM 38.8), appendix (RPKM 13.8) and 5 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    22q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38957609..38963184)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39427986..39433575)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39353614..39359189)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39260057-39260936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39260937-39261814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39261933-39262744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:39268427-39268977 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:39269364-39270563 Neighboring gene chromobox 6 Neighboring gene uncharacterized LOC105373032 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63270 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63315 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63367 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_63385 and experimental_63387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39332328-39333149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39345610-39346460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39350327-39351206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39359385-39360194 Neighboring gene uncharacterized LOC105373033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39361630-39362609 Neighboring gene uncharacterized LOC124905118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo. Naumann JA, et al. Int J Mol Sci, 2023 May 26. PMID 37298259, Free PMC Article
    2. Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression. Göttig L, et al. mBio, 2023 Jun 27. PMID 37154747, Free PMC Article
    3. The role of APOBEC3A in cervical cancer development and progression: A retrospective study. Zhang M, et al. Drug Discov Ther, 2023 Jul 12. PMID 36889736
    4. Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome. Nakata Y, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36610792, Free PMC Article
    5. Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny. Løvestad AH, et al. Tumour Virus Res, 2022 Dec. PMID 36100161, Free PMC Article

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry.
      Title: Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry.
    2. Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.
      Title: Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.
    3. Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.
      Title: Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.
    4. Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage.
      Title: Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage.
    5. Unraveling the Enzyme-Substrate Properties for APOBEC3A-Mediated RNA Editing.
      Title: Unraveling the Enzyme-Substrate Properties for APOBEC3A-Mediated RNA Editing.
    6. Therapy-induced APOBEC3A drives evolution of persistent cancer cells.
      Title: Therapy-induced APOBEC3A drives evolution of persistent cancer cells.
    7. The role of APOBEC3A in cervical cancer development and progression: A retrospective study.
      Title: The role of APOBEC3A in cervical cancer development and progression: A retrospective study.
    8. Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression.
      Title: Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression.
    9. Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A.
      Title: Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A.
    10. DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.
      Title: DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (124)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Phorbolin I, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vif vif Vif(IIIB) induces A3A, A3B, and A3C emigration from the nucleus to the cytosol and thereby causes net increases in their cytosolic concentrations and anti-HIV-1 activities PubMed
    vif HIV-1 Vif reduces cellular expression and packaging of A3G-3A chimera PubMed
    vif Stress causes A3A, A3B, A3C, and A3F to co-localize efficiently with Vif(IIIB) and mRNA-PABP1 complexes in stress granules PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of APOBEC3A in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables deoxycytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxycytidine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA cytosine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clearance of foreign intracellular DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine deamination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytidine to uridine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrotransposon silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA dC->dU-editing enzyme APOBEC-3A
    Names
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
    phorbolin-1
    probable DNA dC->dU-editing enzyme APOBEC-3A
    NP_001257335.1
    NP_663745.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270406.2 → NP_001257335.1  DNA dC->dU-editing enzyme APOBEC-3A isoform b

      See identical proteins and their annotated locations for NP_001257335.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site at the 5' end of a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL022318, BC144146, BI029063
      UniProtKB/TrEMBL
      A0A0K0MJ25, B7ZLZ1
      Conserved Domains (3) summary
      cd01283
      Location:10 → 102
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:116 → 161
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:10 → 173
      APOBEC_N; APOBEC-like N-terminal domain

    2. NM_145699.4 → NP_663745.1  DNA dC->dU-editing enzyme APOBEC-3A isoform a

      See identical proteins and their annotated locations for NP_663745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL022318, BC126416, BI029063, DB322320, U03891
      Consensus CDS
      CCDS13981.1
      UniProtKB/Swiss-Prot
      A0AVM1, P31941, Q12807, Q5JZ93, Q9UH18
      UniProtKB/TrEMBL
      A0A0K0MJ25, A0A0K0MJ49
      Related
      ENSP00000249116.2, ENST00000249116.7
      Conserved Domains (1) summary
      pfam08210
      Location:18 → 191
      APOBEC_N; APOBEC-like N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38957609..38963184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      39427986..39433575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31941.3 GenPept UniProtKB/Swiss-Prot:P31941

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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