Format

Send to:

Choose Destination
    • Showing Current items.

    Ptgs1 prostaglandin-endoperoxide synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19224, updated on 13-Jan-2020

    Summary

    Official Symbol
    Ptgs1provided by MGI
    Official Full Name
    prostaglandin-endoperoxide synthase 1provided by MGI
    Primary source
    MGI:MGI:97797
    See related
    Ensembl:ENSMUSG00000047250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1
    Summary
    This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 9.1), bladder adult (RPKM 9.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Ptgs1 in Genome Data Viewer
    Location:
    2 B; 2 24.19 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36216742..36258593)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (36085946..36107789)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 18 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene predicted gene, 46735 Neighboring gene olfactory receptor 334, pseudogene 1 Neighboring gene olfactory receptor 335, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin-endoperoxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cyclooxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of permeability of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prostaglandin G/H synthase 1
    Names
    PGH synthase 1
    cyclooxygenase-1
    prostaglandin H2 synthase 1
    NP_032995.1
    XP_006497853.1
    XP_006497854.1
    XP_006497857.1
    XP_011237338.1
    XP_017171985.1
    XP_030104501.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008969.4NP_032995.1  prostaglandin G/H synthase 1 precursor

      See identical proteins and their annotated locations for NP_032995.1

      Status: REVIEWED

      Source sequence(s)
      AK159907, AW493573
      Consensus CDS
      CCDS15970.1
      UniProtKB/Swiss-Prot
      P22437
      UniProtKB/TrEMBL
      Q543T1
      Related
      ENSMUSP00000059977.5, ENSMUST00000062069.5
      Conserved Domains (2) summary
      cd09816
      Location:92578
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:3572
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

      Range
      36216742..36258593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248641.1XP_030104501.1  prostaglandin G/H synthase 1 isoform X3

    2. XM_011239036.3XP_011237338.1  prostaglandin G/H synthase 1 isoform X1

      See identical proteins and their annotated locations for XP_011237338.1

      UniProtKB/Swiss-Prot
      P22437
      UniProtKB/TrEMBL
      Q543T1
      Conserved Domains (2) summary
      cd09816
      Location:92578
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:3572
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. XM_006497790.4XP_006497853.1  prostaglandin G/H synthase 1 isoform X1

      See identical proteins and their annotated locations for XP_006497853.1

      UniProtKB/Swiss-Prot
      P22437
      UniProtKB/TrEMBL
      Q543T1
      Conserved Domains (2) summary
      cd09816
      Location:92578
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:3572
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    4. XM_006497791.4XP_006497854.1  prostaglandin G/H synthase 1 isoform X1

      See identical proteins and their annotated locations for XP_006497854.1

      UniProtKB/Swiss-Prot
      P22437
      UniProtKB/TrEMBL
      Q543T1
      Conserved Domains (2) summary
      cd09816
      Location:92578
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:3572
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    5. XM_017316496.2XP_017171985.1  prostaglandin G/H synthase 1 isoform X1

      UniProtKB/Swiss-Prot
      P22437
      UniProtKB/TrEMBL
      Q543T1
      Conserved Domains (2) summary
      cd09816
      Location:92578
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:3572
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    6. XM_006497794.4XP_006497857.1  prostaglandin G/H synthase 1 isoform X2

      Conserved Domains (2) summary
      cd09816
      Location:74560
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:1754
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Support Center