asic-1 Degenerin-like protein asic-1 [Caenorhabditis elegans] - Gene

Summary

Gene symbol: asic-1
Gene description: Degenerin-like protein asic-1
Primary source: WormBase:WBGene00022815
Locus tag: CELE_ZK770.1
See related: AllianceGenome:WB:WBGene00022815
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acid-sensing ion channel activity. Involved in positive regulation of dopamine secretion. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta) and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables pH-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

NP_491214.3

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The following sections contain reference sequences that belong to a specific genome build. Explain