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    ins-33 INSulin related [ Caenorhabditis elegans ]

    Gene ID: 189313, updated on 7-Sep-2023

    Summary

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    Gene symbol
    ins-33
    Gene description
    INSulin related
    Primary source
    WormBase:WBGene00002116
    Locus tag
    CELE_W09C5.4
    See related
    AllianceGenome:WB:WBGene00002116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hormone activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Is expressed in head muscle; head neurons; hypodermis; intestine; and tail. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (13637845..13639311, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase dkf-1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin signaling promotes germline proliferation in C. elegans. Michaelson D, et al. Development, 2010 Feb. PMID 20110332, Free PMC Article
    2. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest. Chen Y, et al. Dev Biol, 2014 Oct 15. PMID 25128585
    3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
    4. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283
    5. Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans. Liu T, et al. BMC Dev Biol, 2004 Sep 20. PMID 15380030, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic analysis indicates that the developmental regulation of ins-33 mRNA involves the stage-specific repression of ins-33 transcription by LIN-14 via sequence-specific DNA binding.
      Title: The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    INSulin related
    NP_493389.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13637845..13639311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060988.4 → NP_493389.1  INSulin related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493389.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U333
    Nucleotide Protein
    Heading Accession and Version

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