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    sptf-2 Specificity protein transcription factor 2 [ Caenorhabditis elegans ]

    Gene ID: 188733, updated on 23-Nov-2023

    Summary

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    Gene symbol
    sptf-2
    Gene description
    Specificity protein transcription factor 2
    Primary source
    WormBase:WBGene00011926
    Locus tag
    CELE_T22C8.5
    See related
    AllianceGenome:WB:WBGene00011926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in head neurons and intestine. Orthologous to human KLF10 (Kruppel like factor 10) and SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8625459..8627622)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Ntox44 domain-containing protein Neighboring gene ZP domain-containing protein Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene Transmembrane protein 47

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of an activated beta-catenin to identify Wnt pathway target genes in caenorhabditis elegans, including a subset of collagen genes expressed in late larval development. Jackson BM, et al. G3 (Bethesda), 2014 Apr 16. PMID 24569038, Free PMC Article
    2. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Specificity protein transcription factor 2
    NP_495833.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8625459..8627622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063432.2 → NP_495833.1  Specificity protein transcription factor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22678
      Conserved Domains (2) summary
      COG5048
      Location:75 → 156
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82 → 101
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22678.1

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