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    T14B4.9 Core-2/I-Branching enzyme [ Caenorhabditis elegans ]

    Gene ID: 188494, updated on 7-Sep-2023

    Summary

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    Gene symbol
    T14B4.9
    Gene description
    Core-2/I-Branching enzyme
    Primary source
    WormBase:WBGene00020503
    Locus tag
    CELE_T14B4.9
    See related
    AllianceGenome:WB:WBGene00020503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycosyltransferase activity. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to several human genes including GCNT1 (glucosaminyl (N-acetyl) transferase 1); GCNT2 (glucosaminyl (N-acetyl) transferase 2 (I blood group)); and GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (6730152..6733818, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ANAPC4_WD40 domain-containing protein;DPPIV_N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene 28S ribosomal protein S18c, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Core-2/I-Branching enzyme
    NP_495371.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6730152..6733818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062970.4 → NP_495371.2  Core-2/I-Branching enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495371.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22481
      Conserved Domains (1) summary
      pfam02485
      Location:108 → 375
      Branch; Core-2/I-Branching enzyme
    Nucleotide Protein
    Heading Accession and Version

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