ser-5 G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Gene symbol: ser-5
Gene description: G-protein coupled receptors family 1 profile domain-containing protein
Primary source: WormBase:WBGene00008890
Locus tag: CELE_F16D3.7
See related: AllianceGenome:WB:WBGene00008890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha1-adrenergic receptor activity. Involved in positive regulation of oviposition. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in body wall musculature; egg-laying apparatus; intestine; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A); ADRA1B (adrenoceptor alpha 1B); and ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

SER-5 increases the responsiveness of the afferent neurons to the volatile repellent, dilute octanol.
Title: Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Preferred Names: G-protein coupled receptors family 1 profile domain-containing protein

NP_492273.2

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The following sections contain reference sequences that belong to a specific genome build. Explain