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    hlh-8 Twist-related protein [ Caenorhabditis elegans ]

    Gene ID: 181069, updated on 23-Nov-2023

    Summary

    Gene symbol
    hlh-8
    Gene description
    Twist-related protein
    Primary source
    WormBase:WBGene00001953
    Locus tag
    CELE_C02B8.4
    See related
    AllianceGenome:WB:WBGene00001953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and vulval cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including M cell; M.dlpa male; M.drpa male; anal depressor muscle; and body muscle cell. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in Barber-Say syndrome; Sweeney-Cox syndrome; ablepharon macrostomia syndrome; focal dermal hypoplasia; and synostosis (multiple). Orthologous to several human genes including TWIST1 (twist family bHLH transcription factor 1) and TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See hlh-8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (8116457..8120340)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Bromo domain-containing protein Neighboring gene ncRNA Neighboring gene Cpw-wpc domain-containing protein Neighboring gene putative G-protein coupled receptor frpr-1 Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Twist-related protein
    NP_509367.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8116457..8120340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076966.3NP_509367.1  Twist-related protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76255, Q11094
      Conserved Domains (1) summary
      pfam00010
      Location:2171
      HLH; Helix-loop-helix DNA-binding domain