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    efl-1 E2F/DP family winged-helix DNA-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180133, updated on 23-Nov-2023

    Summary

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    Gene symbol
    efl-1
    Gene description
    E2F/DP family winged-helix DNA-binding domain-containing protein
    Primary source
    WormBase:WBGene00001161
    Locus tag
    CELE_Y102A5C.18
    See related
    AllianceGenome:WB:WBGene00001161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein C-terminus binding activity and protein N-terminus binding activity. Involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in gonad. Orthologous to human E2F4 (E2F transcription factor 4) and E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (16958590..16965675, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene C-type lectin domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Li J, et al. Genes Dev, 2016 Sep 15. PMID 27688402, Free PMC Article
    2. The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans. Miller JG, et al. G3 (Bethesda), 2016 Jan 15. PMID 26772748, Free PMC Article
    3. Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes. Goetsch PD, et al. PLoS Genet, 2017 Nov. PMID 29091720, Free PMC Article
    4. lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Davison EM, et al. Genetics, 2005 Nov. PMID 16020796, Free PMC Article
    5. dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Ceol CJ, et al. Mol Cell, 2001 Mar. PMID 11463372

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2F and HSF-1 directly regulate a gene network, including a specific subset of chaperones, to promote protein biogenesis and anabolic metabolism, which are essential in development.
      Title: E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.
    2. Efl-1 regulates organismal senescence by inhibiting daf-16.
      Title: E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.
    3. Efl-1/E2F and other SynMuv B genes negatively regulate a component of the anaphase-promoting complex or cyclosome (APC/C).
      Title: Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.
    4. Many EFL-1/DPL-1 responsive genes encode proteins required for oogenesis and early embryogenesis, rather than cell cycle components.
      Title: Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB).
    5. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death.
      Title: DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E2F/DP family winged-helix DNA-binding domain-containing protein
    NP_507289.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16958590..16965675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074888.7 → NP_507289.1  E2F/DP family winged-helix DNA-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF11
      Conserved Domains (3) summary
      cd14660
      Location:152 → 187
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:67 → 131
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam16421
      Location:157 → 254
      E2F_CC-MB; E2F transcription factor CC-MB domain
    Nucleotide Protein
    Heading Accession and Version

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