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    nhr-31 Nuclear hormone receptor family member nhr-31 [ Caenorhabditis elegans ]

    Gene ID: 177601, updated on 20-Oct-2023

    Summary

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    Gene symbol
    nhr-31
    Gene description
    Nuclear hormone receptor family member nhr-31
    Primary source
    WormBase:WBGene00003625
    Locus tag
    CELE_C26B2.3
    See related
    AllianceGenome:WB:WBGene00003625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in embryo development; post-embryonic animal morphogenesis; and response to osmotic stress. Predicted to be located in nucleus. Is expressed in excretory cell. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (8022655..8029513, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Elongator complex protein 4 Neighboring gene Dynactin subunit 4 Neighboring gene Membrane-associated kinase regulator Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase. Hahn-Windgassen A, et al. PLoS Genet, 2009 Jul. PMID 19668342, Free PMC Article
    2. Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans. Zima V, et al. Folia Biol (Praha), 2015. PMID 26667573
    3. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. Murphy JT, et al. PLoS Biol, 2019 May. PMID 31086360, Free PMC Article
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNF4-type plays roles in the development and function of a renal system.
      Title: The Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic animal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-31
    NP_001379703.1
    • Confirmed by transcript evidence
    NP_741456.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8022655..8029513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171391.7 → NP_741456.1  Nuclear hormone receptor family member nhr-31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18192, Q5TYL7, Q8MQB8
      UniProtKB/TrEMBL
      Q9GTI0
      Conserved Domains (2) summary
      cd06157
      Location:259 → 423
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd06960
      Location:82 → 157
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    2. NM_001392341.1 → NP_001379703.1  Nuclear hormone receptor family member nhr-31 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTH9
      Conserved Domains (2) summary
      cd06157
      Location:220 → 384
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd06960
      Location:43 → 118
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    RNA

    1. NR_131580.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18192.2

    Gene LinkOut

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