iff-1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Translation elongation factor IF5A C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: iff-1
Gene description: Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Translation elongation factor IF5A C-terminal domain-containing protein
Primary source: WormBase:WBGene00002064
Locus tag: CELE_T05G5.10
See related: AllianceGenome:WB:WBGene00002064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable translation elongation factor activity. Involved in gamete generation and protein localization. Predicted to be located in cytoplasm. Is expressed in germ line and gonad. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A) and EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (9745862..9747193, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFF-1 is required in the germline for germ cell proliferation, for gametogenesis after entry into meiosis, and for proper PGL-1 localization on P granules.
Title: The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05G5.3 (e-PCR)
- UniSTS:307932

T05G5.10 (e-PCR)
- UniSTS:318430

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Translation elongation factor IF5A C-terminal domain-containing protein

NP_001255020.1

Confirmed by transcript evidence

NP_001255021.1

Confirmed by transcript evidence

NP_001255022.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9745862..9747193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268091.4 → NP_001255020.1 Eukaryotic translation initiation factor 5A-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255020.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34563

Conserved Domains (2) summary

PLN03107
Location:40 → 190

PLN03107; eukaryotic translation initiation factor 5A; Provisional

cd04468
Location:122 → 192

S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
NM_001268092.3 → NP_001255021.1 Eukaryotic translation initiation factor 5A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255021.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34563

UniProtKB/TrEMBL

G1K0V8

Conserved Domains (2) summary

PLN03107
Location:6 → 156

PLN03107; eukaryotic translation initiation factor 5A; Provisional

cd04468
Location:88 → 158

S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
NM_001268093.3 → NP_001255022.1 Translation elongation factor IF5A C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255022.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K0V9

Conserved Domains (1) summary

cl09927
Location:1 → 63

S1_like; Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains ...