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    best-24 Bestrophin homolog 24 [ Caenorhabditis elegans ]

    Gene ID: 176110, updated on 11-Apr-2024

    Summary

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    Gene symbol
    best-24
    Gene description
    Bestrophin homolog 24
    Primary source
    WormBase:WBGene00022797
    Locus tag
    CELE_ZK688.2
    See related
    AllianceGenome:WB:WBGene00022797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of chloride channel complex. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human BEST2 (bestrophin 2) and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See best-24 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (7901033..7904473)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene Prolyl carboxy peptidase like protein 5 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bestrophin homolog 24
    NP_498717.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7901033..7904473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066316.8 → NP_498717.1  Bestrophin homolog 24 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34672
      Conserved Domains (1) summary
      pfam01062
      Location:9 → 315
      Bestrophin; Bestrophin, RFP-TM, chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34672.1

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