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    rnh-1.1 RNase H type-1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174222, updated on 23-Nov-2023

    Summary

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    Gene symbol
    rnh-1.1
    Gene description
    RNase H type-1 domain-containing protein
    Primary source
    WormBase:WBGene00022888
    Locus tag
    CELE_ZK1290.6
    See related
    AllianceGenome:WB:WBGene00022888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA-DNA hybrid ribonuclease activity. Involved in RNA phosphodiester bond hydrolysis, endonucleolytic. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (7525738..7528239)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene putative oxidoreductase ZK1290.5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Arudchandran A, et al. Mol Biol Evol, 2002 Nov. PMID 12411600
    2. Stage-specific expression of Caenorhabditis elegans ribonuclease H1 enzymes with different substrate specificities and bivalent cation requirements. Kochiwa H, et al. FEBS J, 2006 Jan. PMID 16403028
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, removal of RNA primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNase H type-1 domain-containing protein
    NP_001022508.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7525738..7528239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027337.4 → NP_001022508.1  RNase H type-1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09633
      Conserved Domains (1) summary
      cd09280
      Location:328 → 457
      RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
    Nucleotide Protein
    Heading Accession and Version

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