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    egl-44 TEA domain-containing protein;Transcription enhancer factor-like protein egl-44 [ Caenorhabditis elegans ]

    Gene ID: 174005, updated on 23-Nov-2023

    Summary

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    Gene symbol
    egl-44
    Gene description
    TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
    Primary source
    WormBase:WBGene00001208
    Locus tag
    CELE_F28B12.2
    See related
    AllianceGenome:WB:WBGene00001208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator binding activity. Involved in generation of neurons; positive regulation of exit from mitosis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior hypodermis; body wall musculature; ganglia; neurons; and pharynx. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD3 (TEA domain transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (5928830..5940830)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase VRK1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YAP in epithelium senses gut barrier loss to deploy defenses against pathogens. Ma YC, et al. PLoS Pathog, 2020 Aug. PMID 32857822, Free PMC Article
    2. Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans. Wu J, et al. Genes Dev, 2001 Mar 15. PMID 11274062, Free PMC Article
    3. Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron. O'Brien BMJ, et al. Dev Biol, 2017 Dec 15. PMID 29031632, Free PMC Article
    4. Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Smith CJ, et al. Dev Biol, 2010 Sep 1. PMID 20537990, Free PMC Article
    5. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Iwasa H, et al. Exp Cell Res, 2013 Feb 1. PMID 23103556

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
    NP_001343765.1
    • Confirmed by transcript evidence
    NP_001343766.1
    • Confirmed by transcript evidence
    NP_001343767.1
    • Confirmed by transcript evidence
    NP_001343768.1
    • Confirmed by transcript evidence
    NP_001367307.1
    • Confirmed by transcript evidence
    NP_001368664.1
    • Confirmed by transcript evidence
    NP_001370297.1
    • Confirmed by transcript evidence
    NP_495186.3
    • Confirmed by transcript evidence
    NP_741006.3
    • Confirmed by transcript evidence
    NP_741007.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5928830..5940830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356848.3 → NP_001343765.1  TEA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3H3
      Conserved Domains (2) summary
      smart00426
      Location:89 → 156
      TEA; TEA domain
      pfam17725
      Location:287 → 483
      YBD; YAP binding domain

    2. NM_001356849.3 → NP_001343766.1  TEA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3C4
      Conserved Domains (2) summary
      smart00426
      Location:89 → 156
      TEA; TEA domain
      pfam17725
      Location:280 → 476
      YBD; YAP binding domain

    3. NM_171850.7 → NP_741007.2  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741007.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D7SFJ5, D7SFJ6, D7SFJ7, D7SFJ8, D7SFJ9, Q19849, Q86NH3, Q86NH4, Q86NH5, Q86NH6, Q95QI4, Q9GT31
      Conserved Domains (1) summary
      smart00426
      Location:90 → 157
      TEA; TEA domain

    4. NM_001356850.3 → NP_001343767.1  TEA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2P8
      Conserved Domains (2) summary
      smart00426
      Location:90 → 157
      TEA; TEA domain
      pfam17725
      Location:288 → 484
      YBD; YAP binding domain

    5. NM_171007.6 → NP_741006.3  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741006.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19849
      Conserved Domains (1) summary
      smart00426
      Location:75 → 142
      TEA; TEA domain

    6. NM_062785.6 → NP_495186.3  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495186.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19849
      Conserved Domains (1) summary
      smart00426
      Location:75 → 142
      TEA; TEA domain

    7. NM_001381441.3 → NP_001367307.1  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00426
      Location:32 → 99
      TEA; TEA domain
      pfam17725
      Location:230 → 426
      YBD; YAP binding domain

    8. NM_001381442.1 → NP_001368664.1  TEA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C333
      Conserved Domains (2) summary
      smart00426
      Location:32 → 99
      TEA; TEA domain
      pfam17725
      Location:223 → 419
      YBD; YAP binding domain

    9. NM_001383853.2 → NP_001370297.1  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00426
      Location:15 → 82
      TEA; TEA domain
      pfam17725
      Location:206 → 402
      YBD; YAP binding domain

    10. NM_001356852.4 → NP_001343768.1  TEA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2W1
      Conserved Domains (2) summary
      smart00426
      Location:15 → 82
      TEA; TEA domain
      pfam17725
      Location:213 → 409
      YBD; YAP binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19849.4

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