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    cup-2 Derlin-1 [ Caenorhabditis elegans ]

    Gene ID: 172915, updated on 11-Apr-2024

    Summary

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    Gene symbol
    cup-2
    Gene description
    Derlin-1
    Primary source
    WormBase:WBGene00000843
    Locus tag
    CELE_F25D7.1
    See related
    AllianceGenome:WB:WBGene00000843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable misfolded protein binding activity; signal recognition particle binding activity; and ubiquitin-specific protease binding activity. Involved in endocytosis and response to misfolded protein. Located in early endosome and perinuclear endoplasmic reticulum. Is expressed widely. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See cup-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (10398990..10400177, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clathrin-mediated endocytosis is involved in uptake and toxicity of silica nanoparticles in Caenohabditis elegans. Eom HJ, et al. Chem Biol Interact, 2019 Sep 25. PMID 31369748
    2. Derlin-dependent retrograde transport from endosomes to the Golgi apparatus. Dang H, et al. Traffic, 2011 Oct. PMID 21722281, Free PMC Article
    3. RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin. Darom A, et al. Mol Biol Cell, 2010 Jun 1. PMID 20357004, Free PMC Article
    4. The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3. He L, et al. Dis Model Mech, 2012 Nov. PMID 22569626, Free PMC Article
    5. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Ye Y, et al. Nature, 2004 Jun 24. PMID 15215856

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Derlin-1
    NP_492721.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10398990..10400177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060320.8 → NP_492721.1  Derlin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93561
      Conserved Domains (1) summary
      pfam04511
      Location:10 → 202
      DER1; Der1-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93561.1

    Gene LinkOut

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