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    M04F3.5 IMD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172093, updated on 11-Apr-2024

    Summary

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    Gene symbol
    M04F3.5
    Gene description
    IMD domain-containing protein
    Primary source
    WormBase:WBGene00019771
    Locus tag
    CELE_M04F3.5
    See related
    AllianceGenome:WB:WBGene00019771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and phospholipid binding activity. Involved in cell projection assembly and membrane organization. Located in filopodium. Is intrinsic component of the cytoplasmic side of the plasma membrane. Is expressed in head ganglion; head neurons; and pharynx. Orthologous to human MTSS1 (MTSS I-BAR domain containing 1) and MTSS2 (MTSS I-BAR domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (4773819..4788358, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Replication protein A C-terminal domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L41 Neighboring gene 60S ribosomal protein L41

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanisms of membrane deformation by I-BAR domain proteins. Saarikangas J, et al. Curr Biol, 2009 Jan 27. PMID 19150238
    2. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular anatomical entity IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    IMD domain-containing protein
    NP_001317862.1
    • Confirmed by transcript evidence
    NP_491448.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4773819..4788358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330926.5 → NP_001317862.1  IMD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSH3
      Conserved Domains (1) summary
      cl12013
      Location:9 → 195
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_059047.8 → NP_491448.2  IMD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491448.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y95
      Conserved Domains (1) summary
      cl12013
      Location:6 → 192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version

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