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    ZNF846 zinc finger protein 846 [ Homo sapiens (human) ]

    Gene ID: 162993, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF846provided by HGNC
    Official Full Name
    zinc finger protein 846provided by HGNC
    Primary source
    HGNC:HGNC:27260
    See related
    Ensembl:ENSG00000196605 AllianceGenome:HGNC:27260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 2.6), brain (RPKM 2.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9748619..9786160, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9874759..9912301, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9859295..9896836, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372270 Neighboring gene zinc finger protein 562 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9879342-9880207 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:9889978-9890153 Neighboring gene ubiquitin conjugating enzyme E2 L4 (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9894821-9895652 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9895653-9896484 Neighboring gene uncharacterized LOC100505555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10041 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9903248-9903748 Neighboring gene uncharacterized LOC124904635 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9903749-9904249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10044 Neighboring gene F-box and leucine rich repeat protein 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. Li Y, et al. Cell Death Discov, 2022 Mar 9. PMID 35264565, Free PMC Article
    2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 846
    Names
    zinc finger protein 420 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077624.3 → NP_001071092.1  zinc finger protein 846 isoform 1

      See identical proteins and their annotated locations for NP_001071092.1

      Status: VALIDATED

      Source sequence(s)
      AC008752
      Consensus CDS
      CCDS42496.1
      UniProtKB/Swiss-Prot
      A8K0H1, B3KUP1, Q147U1
      Related
      ENSP00000380999.1, ENST00000397902.7
      Conserved Domains (6) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:106 → 496
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:368 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:338 → 360
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 45
      KRAB; KRAB box
      pfam13465
      Location:464 → 489
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001353798.2 → NP_001340727.1  zinc finger protein 846 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008752
      Conserved Domains (2) summary
      COG5048
      Location:2 → 367
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001353799.2 → NP_001340728.1  zinc finger protein 846 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008752
      Conserved Domains (3) summary
      smart00349
      Location:8 → 66
      KRAB; krueppel associated box
      COG5048
      Location:105 → 495
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001353800.3 → NP_001340729.1  zinc finger protein 846 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) initiates at an upstream alternate promoter and differs at both the 5' and 3' ends compared to variant 1. The encoded isoform (4) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (3) summary
      smart00349
      Location:8 → 66
      KRAB; krueppel associated box
      COG5189
      Location:249 → 327
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001395830.1 → NP_001382759.1  zinc finger protein 846 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5189
      Location:250 → 328
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001395831.1 → NP_001382760.1  zinc finger protein 846 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5189
      Location:250 → 328
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001395832.1 → NP_001382761.1  zinc finger protein 846 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5189
      Location:250 → 328
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001395833.1 → NP_001382762.1  zinc finger protein 846 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (2) summary
      COG5189
      Location:214 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:192 → 212
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001395834.1 → NP_001382763.1  zinc finger protein 846 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (2) summary
      COG5189
      Location:214 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:192 → 212
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001395835.1 → NP_001382764.1  zinc finger protein 846 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (3) summary
      COG5189
      Location:213 → 291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 30
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    11. NM_001395836.1 → NP_001382765.1  zinc finger protein 846 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (2) summary
      COG5189
      Location:193 → 271
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001395837.1 → NP_001382766.1  zinc finger protein 846 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (2) summary
      COG5189
      Location:193 → 271
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001395838.1 → NP_001382767.1  zinc finger protein 846 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Conserved Domains (2) summary
      COG5189
      Location:151 → 229
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_001395839.1 → NP_001382768.1  zinc finger protein 846 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Consensus CDS
      CCDS92508.1
      Conserved Domains (2) summary
      COG5189
      Location:121 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:99 → 119
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. NM_001395840.1 → NP_001382769.1  zinc finger protein 846 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Consensus CDS
      CCDS92508.1
      Conserved Domains (2) summary
      COG5189
      Location:121 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:99 → 119
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. NM_001395841.1 → NP_001382770.1  zinc finger protein 846 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Consensus CDS
      CCDS92508.1
      Conserved Domains (2) summary
      COG5189
      Location:121 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:99 → 119
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. NM_001395842.1 → NP_001382771.1  zinc finger protein 846 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Consensus CDS
      CCDS92508.1
      Related
      ENSP00000467891.1, ENST00000592859.1
      Conserved Domains (2) summary
      COG5189
      Location:121 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:99 → 119
      ZF_C2H2; C2H2 Zn finger [structural motif]

    18. NM_001395843.1 → NP_001382772.1  zinc finger protein 846 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759
      Consensus CDS
      CCDS92508.1
      Conserved Domains (2) summary
      COG5189
      Location:121 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:99 → 119
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_172869.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759

    2. NR_172870.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759

    3. NR_172871.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759

    4. NR_172872.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759

    5. NR_172873.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008752, AC008759

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9748619..9786160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9874759..9912301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_024149.1: Suppressed sequence

      Description
      NG_024149.1: This RefSeq was removed because it is primarily UTR sequence.

    2. NR_148544.1: Suppressed sequence

      Description
      NR_148544.1: This RefSeq was removed because currently there is no support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q147U1.2 GenPept UniProtKB/Swiss-Prot:Q147U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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