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    Asic2 acid-sensing ion channel 2 [ Mus musculus (house mouse) ]

    Gene ID: 11418, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Asic2provided by MGI
    Official Full Name
    acid-sensing ion channel 2provided by MGI
    Primary source
    MGI:MGI:1100867
    See related
    Ensembl:ENSMUSG00000020704 AllianceGenome:MGI:1100867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BNC1; Mdeg; ACIC2; Accn1; BNaC1; BNaC1a
    Summary
    Enables ion gated channel activity and ligand-gated sodium channel activity. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.0), ovary adult (RPKM 9.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asic2 in Genome Data Viewer
    Location:
    11 B5; 11 48.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80770989..81859222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80880163..81968396, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930507D10 gene Neighboring gene sperm acrosome associated 3 Neighboring gene predicted gene, 51909 Neighboring gene STARR-seq mESC enhancer starr_30154 Neighboring gene predicted gene 11416 Neighboring gene STARR-seq mESC enhancer starr_30155 Neighboring gene STARR-seq mESC enhancer starr_30156 Neighboring gene STARR-seq mESC enhancer starr_30157 Neighboring gene STARR-seq mESC enhancer starr_30158 Neighboring gene predicted gene, 51910 Neighboring gene predicted gene, 42084 Neighboring gene STARR-seq mESC enhancer starr_30159 Neighboring gene STARR-seq mESC enhancer starr_30160 Neighboring gene STARR-seq mESC enhancer starr_30161 Neighboring gene RIKEN cDNA 1700071K01 gene Neighboring gene predicted gene 11418 Neighboring gene STARR-seq mESC enhancer starr_30167 Neighboring gene STARR-seq mESC enhancer starr_30168 Neighboring gene STARR-seq mESC enhancer starr_30169 Neighboring gene RIKEN cDNA 5530401A14 gene Neighboring gene predicted gene, 46254 Neighboring gene STARR-seq mESC enhancer starr_30170 Neighboring gene predicted gene 11419 Neighboring gene predicted gene, 31522 Neighboring gene C-C motif chemokine ligand 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension. Detweiler ND, et al. J Appl Physiol (1985), 2019 Aug 1. PMID 31169471, Free PMC Article
    2. Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus. Lee JS, et al. J Gen Physiol, 2019 Jul 1. PMID 31010811, Free PMC Article
    3. Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury. Jiang N, et al. J Cereb Blood Flow Metab, 2017 Feb. PMID 26861816, Free PMC Article
    4. Two di-leucine motifs regulate trafficking and function of mouse ASIC2a. Wu J, et al. Mol Brain, 2016 Jan 27. PMID 26819004, Free PMC Article
    5. Altered myogenic vasoconstriction and regulation of whole kidney blood flow in the ASIC2 knockout mouse. Gannon KP, et al. Am J Physiol Renal Physiol, 2015 Feb 15. PMID 25520010, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
      Title: The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
    2. Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.
      Title: Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.
    3. Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension.
      Title: Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension.
    4. Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus.
      Title: Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus.
    5. Findings suggest a potential role of ASIC 2 in the pathophysiology of multiple sclerosis.
      Title: Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis.
    6. ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells.
      Title: Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells.
    7. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
      Title: Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke.
    8. ASIC2 deletion significantly protected the mouse brain from ischemic damage in vivo.
      Title: Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury.
    9. Studies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
      Title: The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.
    10. differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b, was investigated.
      Title: ASIC subunit ratio and differential surface trafficking in the brain.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion-gated channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion-gated channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to acidic pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sour taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acid-sensing ion channel 2
    Names
    acid-sensing (proton-gated) ion channel 2
    amiloride-sensitive brain sodium channel
    amiloride-sensitive cation channel 1, neuronal (degenerin)
    brain sodium channel 1
    degenerin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034013.2 → NP_001029185.1  acid-sensing ion channel 2 isoform MDEG1

      See identical proteins and their annotated locations for NP_001029185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MDEG1) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant MDEG2. The resulting isoform (MDEG1) is shorter and has a distinct N-terminus, compared to isoform MDEG2.
      Source sequence(s)
      AK134778, AL645842
      Consensus CDS
      CCDS36243.1
      UniProtKB/Swiss-Prot
      Q5SUU2, Q61203, Q925H0
      UniProtKB/TrEMBL
      Q3UYD3
      Related
      ENSMUSP00000067095.7, ENSMUST00000066197.7
      Conserved Domains (1) summary
      cl02990
      Location:18 → 506
      ASC; Amiloride-sensitive sodium channel

    2. NM_007384.3 → NP_031410.1  acid-sensing ion channel 2 isoform MDEG2

      See identical proteins and their annotated locations for NP_031410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MDEG2) is the longer transcript and encodes the longer isoform (MDEG2).
      Source sequence(s)
      AL645626, BB342826, BC138530, CJ282964
      Consensus CDS
      CCDS25137.1
      UniProtKB/TrEMBL
      B2RRQ1
      Related
      ENSMUSP00000021045.7, ENSMUST00000021045.13
      Conserved Domains (1) summary
      TIGR00859
      Location:64 → 557
      ENaC; sodium channel transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80770989..81859222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531996.5 → XP_006532059.1  acid-sensing ion channel 2 isoform X1

      Conserved Domains (1) summary
      cl02990
      Location:64 → 590
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925H0.1 GenPept UniProtKB/Swiss-Prot:Q925H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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