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    akt1 v-akt murine thymoma viral oncogene homolog 1 [ Danio rerio (zebrafish) ]

    Gene ID: 101910198, updated on 8-Mar-2024

    Summary

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    Official Symbol
    akt1provided by ZNC
    Official Full Name
    v-akt murine thymoma viral oncogene homolog 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130730-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-130730-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Acts upstream of or within negative regulation of neuron differentiation. Is expressed in central nervous system; hindbrain neural rod; pharyngeal arch; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); lung disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (1437377..1533215)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (1708199..1787403)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene SIVA1, apoptosis-inducing factor Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene centrosomal protein 170Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Receptor-Mediated AKT/PI3K Signalling and Behavioural Alterations in Zebrafish Larvae Reveal Association between Schizophrenia and Opioid Use Disorder. Thiagarajan SK, et al. Int J Mol Sci, 2022 Apr 25. PMID 35563106, Free PMC Article
    2. Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine. Perna AF, et al. Int J Mol Sci, 2018 Apr 29. PMID 29710830, Free PMC Article
    3. Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. Luo J, et al. J Exp Clin Cancer Res, 2021 Aug 20. PMID 34416907, Free PMC Article
    4. An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX. Long MJC, et al. Acc Chem Res, 2021 Feb 2. PMID 33228351
    5. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos. Li L, et al. Life Sci, 2016 Jul 15. PMID 27234894

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study has identified Akt as a novel intracellular pathway required for neural crest differentiation.
      Title: A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.
    2. Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
      Title: Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RAC-alpha serine/threonine-protein kinase
    NP_001268730.1
    XP_021322776.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281801.1 → NP_001268730.1  RAC-alpha serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_001268730.1

      Status: PROVISIONAL

      Source sequence(s)
      JX307852
      UniProtKB/TrEMBL
      M4MD44
      Conserved Domains (2) summary
      cd01241
      Location:5 → 112
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:120 → 473
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      1437377..1533215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467101.1 → XP_021322776.1  RAC-alpha serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      M4MD44
      Conserved Domains (2) summary
      cd01241
      Location:5 → 112
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:120 → 473
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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