txnrd1 thioredoxin reductase 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: txnrd1provided by Xenbase
Official Full Name: thioredoxin reductase 1provided by Xenbase
Primary source: Xenbase:XB-GENE-956002
See related: Ensembl:ENSXETG00000019645
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (49907441..49945432)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (40381204..40419251)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEA Inferred from Electronic Annotation more info
enables thioredoxin-disulfide reductase (NADP) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to inorganic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin reductase 1, cytoplasmic

NP_001243400.1

EC 1.8.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256471.1 → NP_001243400.1 thioredoxin reductase 1, cytoplasmic

Status: REVIEWED

Source sequence(s)

AAMC03011186, CF523670, CX974039, DT396290, DT396291

UniProtKB/TrEMBL

A0A6I8R2A8, A0A8J0QGX3

Related

ENSXETP00000078707.2, ENSXETT00000078084.2

Conserved Domains (4) summary

TIGR01438
Location:166 → 653

TGR; thioredoxin and glutathione reductase selenoprotein

pfam00070
Location:347 → 423

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:525 → 635

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

cl00388
Location:73 → 153

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold