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    Zfp42 zinc finger protein 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361947, updated on 13-Apr-2024

    Summary

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    Symbol
    Zfp42provided by RGD
    Full Name
    zinc finger protein 42provided by RGD
    Primary source
    RGD:2319133
    See related
    Ensembl:ENSRNOG00000067356 AllianceGenome:RGD:2319133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp971
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in female gonad development; male gonad development; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of genetic imprinting; and spermatid development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Orthologous to human ZFP42 (ZFP42 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 46.5) and Brain (RPKM 9.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp42 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (55568903..55577883)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (48836463..48845443)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (52016590..52026346)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor co-repressor 1, pseudogene 1 Neighboring gene high-mobility group box 1, pseudogene 28 Neighboring gene ribosomal protein L23,pseudogene 1 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression. Rezende NC, et al. Dev Biol, 2011 Aug 15. PMID 21641340, Free PMC Article
    2. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Raman JD, et al. Carcinogenesis, 2006 Mar. PMID 16344273
    3. Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. Xu J, et al. J Mol Biol, 2008 Mar 14. PMID 18237746, Free PMC Article
    4. Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1. Kim JD, et al. Nucleic Acids Res, 2007. PMID 17478514, Free PMC Article
    5. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Kristensen DM, et al. Hum Reprod, 2008 Apr. PMID 18281244

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within genomic imprinting ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 42 homolog
    Names
    zinc finger protein 971

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402569.1 → NP_001389498.1  zinc finger protein 42 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6ATC5, A6JPS8
      Related
      ENSRNOP00000096008.1, ENSRNOT00000099839.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      55568903..55577883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253172.5 → XP_006253234.1  zinc finger protein 42 homolog isoform X1

      See identical proteins and their annotated locations for XP_006253234.1

      UniProtKB/TrEMBL
      A0A8I6AIJ5, A0A8I6ATC5, A6JPS8
      Related
      ENSRNOP00000093057.1
      Conserved Domains (2) summary
      COG5048
      Location:215 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_039094996.2 → XP_038950924.1  zinc finger protein 42 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIJ5, A0A8I6ATC5, A6JPS8
      Related
      ENSRNOP00000096850.1
      Conserved Domains (2) summary
      COG5048
      Location:215 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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