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    prkcab protein kinase C, alpha, b [ Danio rerio (zebrafish) ]

    Gene ID: 100333967, updated on 21-Apr-2024

    Summary

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    Official Symbol
    prkcabprovided by ZNC
    Official Full Name
    protein kinase C, alpha, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131121-412
    See related
    Ensembl:ENSDARG00000099841 AllianceGenome:ZFIN:ZDB-GENE-131121-412
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-374l24.1; si:ch1073-370j18.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm and membrane. Is expressed in brain and retinal inner nuclear layer. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (56035715..56342888)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (55779923..56275285)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene axin 2 (conductin, axil) Neighboring gene centrosomal protein 112 Neighboring gene calcium channel, voltage-dependent, gamma subunit 5b Neighboring gene cytohesin 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogeny and distribution of protein kinase C variants in the zebrafish. Haug MF, et al. J Comp Neurol, 2018 May 1. PMID 29341136
    2. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma. de Oliveira S, et al. Dis Model Mech, 2020 Apr 30. PMID 32102783, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase C alpha type

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      56035715..56342888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299809.3 → XP_009298084.1  protein kinase C alpha type isoform X1

      UniProtKB/TrEMBL
      A0A8M3AR84
      Related
      ENSDARP00000138087.2, ENSDART00000158540.2
      Conserved Domains (4) summary
      cd04026
      Location:157 → 287
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:347 → 605
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:350 → 668
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:100 → 150
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_009299810.3 → XP_009298085.1  protein kinase C alpha type isoform X2

      UniProtKB/TrEMBL
      A0A8M3B1B9
      Related
      ENSDARP00000138256.2, ENSDART00000166709.2
      Conserved Domains (4) summary
      cd04026
      Location:157 → 287
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:337 → 595
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:340 → 658
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:100 → 150
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version

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