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    efemp1 EGF containing fibulin extracellular matrix protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100332567, updated on 11-Apr-2024

    Summary

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    Official Symbol
    efemp1provided by ZNC
    Official Full Name
    EGF containing fibulin extracellular matrix protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130403-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-130403-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Human ortholog(s) of this gene implicated in Doyne honeycomb retinal dystrophy. Orthologous to human EFEMP1 (EGF containing fibulin extracellular matrix protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (432652..450468, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (302126..320177, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene vitrin Neighboring gene leucine-rich, glioma inactivated 1a Neighboring gene HEAT repeat containing 5B Neighboring gene F-box protein 28 Neighboring gene delta(4)-desaturase, sphingolipid 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
    2. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EGF-containing fibulin-like extracellular matrix protein 1
    Names
    EGF containing fibulin-like extracellular matrix protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      432652..450468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307042.3 → XP_009305317.1  EGF-containing fibulin-like extracellular matrix protein 1

      See identical proteins and their annotated locations for XP_009305317.1

      UniProtKB/TrEMBL
      A0A8M6Z9P8
      Conserved Domains (4) summary
      smart00179
      Location:205 → 239
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:124 → 164
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:163 → 200
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:245 → 276
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. XM_017358907.2 → XP_017214396.1  EGF-containing fibulin-like extracellular matrix protein 1

      UniProtKB/TrEMBL
      A0A8M6Z9P8
      Conserved Domains (4) summary
      smart00179
      Location:205 → 239
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:124 → 164
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:163 → 200
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:245 → 276
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein Strain
    Heading Accession and Version

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