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    abcc8b ATP-binding cassette, sub-family C (CFTR/MRP), member 8b [ Danio rerio (zebrafish) ]

    Gene ID: 100329706, updated on 27-Mar-2024

    Summary

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    Official Symbol
    abcc8bprovided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 8bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120215-45
    See related
    Ensembl:ENSDARG00000077007 AllianceGenome:ZFIN:ZDB-GENE-120215-45
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-347o10.1
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and sulfonylurea receptor activity. Predicted to act upstream of or within potassium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (50040753..50086693, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (50049146..50090122, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 8b Neighboring gene MOB kinase activator 2b Neighboring gene secretory carrier membrane protein 5b Neighboring gene lysyl oxidase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfonylurea receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 8-like
    Names
    zmp:0000001173

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      50040753..50086693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467931.1 → XP_021323606.1  ATP-binding cassette sub-family C member 8-like isoform X5

      UniProtKB/TrEMBL
      A0A8M9PMX8
      Related
      ENSDARP00000136562.3, ENSDART00000165423.3
      Conserved Domains (1) summary
      cl26602
      Location:239 → 1579
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

    2. XM_021467929.1 → XP_021323604.1  ATP-binding cassette sub-family C member 8-like isoform X3

      UniProtKB/TrEMBL
      A0A8M9PG34
      Conserved Domains (1) summary
      cl26602
      Location:239 → 1590
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

    3. XM_021467930.1 → XP_021323605.1  ATP-binding cassette sub-family C member 8-like isoform X4

      UniProtKB/TrEMBL
      A0A8M9PR49
      Related
      ENSDARP00000089439.5, ENSDART00000098668.5
      Conserved Domains (1) summary
      cl26602
      Location:239 → 1586
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

    4. XM_021467928.1 → XP_021323603.1  ATP-binding cassette sub-family C member 8-like isoform X2

      UniProtKB/TrEMBL
      A0A8M9PAN8
      Conserved Domains (1) summary
      cl26602
      Location:239 → 1590
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

    5. XM_021467927.1 → XP_021323602.1  ATP-binding cassette sub-family C member 8-like isoform X1

      UniProtKB/TrEMBL
      A0A8M9P1K6
      Conserved Domains (1) summary
      cl26602
      Location:239 → 1600
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

    6. XM_021467932.1 → XP_021323607.1  ATP-binding cassette sub-family C member 8-like isoform X6

      UniProtKB/TrEMBL
      A0A8M9P1L1
      Conserved Domains (1) summary
      cl26602
      Location:239 → 758
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases