U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    runx2 RUNX family transcription factor 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100189546, updated on 8-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    runx2provided by Xenbase
    Official Full Name
    RUNX family transcription factor 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-482021
    See related
    Ensembl:ENSXETG00000001397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    ccd; aml3; ccd1; osf2; cbfa1; pea2aa; X-runx2; Xlrunx2; pebp2a1; pebp2a2; pebp2aa; pebp2aa1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (147509434..147666873, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (143277075..143433716, complement)

    Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105948523 Neighboring gene uncharacterized LOC116411097 Neighboring gene SPT3 homolog, SAGA and STAGA complex component Neighboring gene cell division cycle 5 like Neighboring gene opsin 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Skeletogenesis in Xenopus tropicalis: characteristic bone development in an anuran amphibian. Miura S, et al. Bone, 2008 Nov. PMID 18692165
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    runt-related transcription factor 2
    Names
    runt related transcription factor 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135116.2 → NP_001128588.1  runt-related transcription factor 2

      See identical proteins and their annotated locations for NP_001128588.1

      Status: PROVISIONAL

      Source sequence(s)
      AB236909
      UniProtKB/TrEMBL
      A0A6I8PZM7, B5BNX8
      Related
      ENSXETP00000060162.1, ENSXETT00000065965.3
      Conserved Domains (2) summary
      pfam00853
      Location:83 → 204
      Runt; Runt domain
      pfam08504
      Location:378 → 468
      RunxI; Runx inhibition domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      147509434..147666873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012970171.3 → XP_012825625.1  runt-related transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A6I8R494, A0A8J0SN14
      Related
      ENSXETP00000075327.1, ENSXETT00000087939.2
      Conserved Domains (2) summary
      pfam00853
      Location:83 → 202
      Runt; Runt domain
      pfam08504
      Location:324 → 414
      RunxI; Runx inhibition domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.