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    Prss3l serine protease 3 like [ Mus musculus (house mouse) ]

    Gene ID: 100040233, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prss3lprovided by MGI
    Official Full Name
    serine protease 3 likeprovided by MGI
    Primary source
    MGI:MGI:3641889
    See related
    Ensembl:ENSMUSG00000071517 AllianceGenome:MGI:3641889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10334
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    6 B1; 6 19.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41419150..41438162, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41442214..41446097, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene T cell receptor beta chain Neighboring gene STARR-seq mESC enhancer starr_15698 Neighboring gene serine protease 1 (trypsin 1) like Neighboring gene Try10-like trypsinogen pseudogene Neighboring gene STARR-seq mESC enhancer starr_15699 Neighboring gene STARR-seq mESC enhancer starr_15700 Neighboring gene serine protease 1 (trypsin 1) Neighboring gene proline-rich polypeptide 3 pseudogene Neighboring gene serine protease 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement. Chen F, et al. J Immunol, 2001 Feb 1. PMID 11160223
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mesotrypsin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_006980.1 

      Range
      551420..555303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103153.2 → NP_001096623.1  mesotrypsin-like precursor

      See identical proteins and their annotated locations for NP_001096623.1

      Status: VALIDATED

      Source sequence(s)
      AC158659
      Consensus CDS
      CCDS39468.1
      UniProtKB/TrEMBL
      B9EJ35, Q792Y8
      Related
      ENSMUSP00000093698.6, ENSMUST00000095999.7
      Conserved Domains (1) summary
      cd00190
      Location:24 → 242
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001411837.1 → NP_001398766.1  mesotrypsin-like precursor

      Status: VALIDATED

      Source sequence(s)
      AC153854, AC158659
      UniProtKB/TrEMBL
      Q792Y8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      41419150..41438162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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