srebf2 sterol regulatory element binding transcription factor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: srebf2provided by ZNC
Official Full Name: sterol regulatory element binding transcription factor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-8
See related: Ensembl:ENSDARG00000063438 AllianceGenome:ZFIN:ZDB-GENE-070410-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158371
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of Notch signaling pathway. Acts upstream of or within liver development. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus. Is expressed in inner ear; liver; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (1107102..1130892)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (1338453..1362243)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fl22a07.x1 (e-PCR)
- UniSTS:202059

G45264 (e-PCR)
- UniSTS:106066

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SREBP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sterol regulatory element-binding protein 2

Names: SREBP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089466.1 → NP_001082935.1 sterol regulatory element-binding protein 2

See identical proteins and their annotated locations for NP_001082935.1

Status: PROVISIONAL

Source sequence(s)

BC133737

UniProtKB/Swiss-Prot

A3KNA7

Related

ENSDARP00000087122.5, ENSDART00000092690.7

Conserved Domains (2) summary

pfam00010
Location:321 → 371

HLH; Helix-loop-helix DNA-binding domain

pfam03153
Location:57 → 221

TFIIA; Transcription factor IIA, alpha/beta subunit