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    fank1 fibronectin type III and ankyrin repeat domains 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100005699, updated on 27-Mar-2024

    Summary

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    Official Symbol
    fank1provided by ZNC
    Official Full Name
    fibronectin type III and ankyrin repeat domains 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130613-3
    See related
    Ensembl:ENSDARG00000039657 AllianceGenome:ZFIN:ZDB-GENE-130613-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be involved in positive regulation of DNA-binding transcription factor activity and regulation of apoptotic process. Located in nucleus. Orthologous to human FANK1 (fibronectin type III and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See fank1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (45132471..45149620, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (44753515..44771256, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-232h12.2 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene uncharacterized LOC101885582 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 32a Neighboring gene BRCA2 and CDKN1A interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Tokumasu Y, et al. Dev Growth Differ, 2016 May. PMID 27185351
    2. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in positive regulation of DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin type 3 and ankyrin repeat domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      45132471..45149620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002664034.6 → XP_002664080.5  fibronectin type 3 and ankyrin repeat domains protein 1

      UniProtKB/TrEMBL
      A0A8M1RRC4, F6NQ86
      Related
      ENSDARP00000057961.4, ENSDART00000057962.5
      Conserved Domains (3) summary
      cd00063
      Location:53 → 144
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00204
      Location:213 → 337
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:254 → 280
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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