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    ablim1a actin binding LIM protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 100003558, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ablim1aprovided by ZNC
    Official Full Name
    actin binding LIM protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080219-41
    See related
    Ensembl:ENSDARG00000060149 AllianceGenome:ZFIN:ZDB-GENE-080219-41
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ablim1; zgc:172321
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly and lamellipodium assembly. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be active in stress fiber. Orthologous to human ABLIM1 (actin binding LIM protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (43507383..43599920, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (43373558..43470576, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SPARC related modular calcium binding 2 Neighboring gene dishevelled-binding antagonist of beta-catenin 2 Neighboring gene FHF complex subunit HOOK interacting protein 2 Neighboring gene zinc finger, FYVE domain containing 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected. Franklin C, et al. Bipolar Disord, 2021 Jun. PMID 32959503
    2. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
    3. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC172321

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding LIM protein 1; actin-binding LIM protein 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114316.1 → NP_001107788.1  actin-binding LIM protein 1a

      See identical proteins and their annotated locations for NP_001107788.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155652
      UniProtKB/TrEMBL
      A9JRG6
      Related
      ENSDARP00000115616.1, ENSDART00000145705.3
      Conserved Domains (6) summary
      smart00153
      Location:658 → 693
      VHP; Villin headpiece domain
      cd09327
      Location:50 → 101
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:106 → 161
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:187 → 238
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:246 → 301
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:311 → 657
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      43507383..43599920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480477.1 → XP_021336152.1  actin-binding LIM protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PXI2
      Conserved Domains (6) summary
      smart00153
      Location:762 → 797
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 761
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. XM_021480476.1 → XP_021336151.1  actin-binding LIM protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QJF9
      Conserved Domains (6) summary
      smart00153
      Location:768 → 803
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 767
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. XM_017358666.2 → XP_017214155.1  actin-binding LIM protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8M6Z1J7

    4. XM_017358665.2 → XP_017214154.1  actin-binding LIM protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8M6Z9H1

    5. XM_009307565.3 → XP_009305840.1  actin-binding LIM protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8M3BEV3
      Conserved Domains (6) summary
      smart00153
      Location:742 → 777
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:222 → 273
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:281 → 336
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:346 → 741
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. XM_009307554.3 → XP_009305829.1  actin-binding LIM protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B5I2
      Conserved Domains (6) summary
      smart00153
      Location:744 → 779
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:222 → 273
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:281 → 336
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:346 → 743
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. XM_021480478.1 → XP_021336153.1  actin-binding LIM protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q9F1
      Conserved Domains (6) summary
      smart00153
      Location:759 → 794
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:222 → 273
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:281 → 336
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:361 → 758
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    8. XM_009307559.3 → XP_009305834.1  actin-binding LIM protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8M3AZG5
      Conserved Domains (6) summary
      smart00153
      Location:704 → 739
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:355 → 703
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    9. XM_009307552.3 → XP_009305827.1  actin-binding LIM protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B896
      Conserved Domains (6) summary
      smart00153
      Location:753 → 788
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:355 → 752
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    10. XM_021480483.1 → XP_021336158.1  actin-binding LIM protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M9Q9F5
      Conserved Domains (6) summary
      smart00153
      Location:689 → 724
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 688
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    11. XM_021480482.1 → XP_021336157.1  actin-binding LIM protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PXI8
      Conserved Domains (6) summary
      smart00153
      Location:691 → 726
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 690
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    12. XM_021480479.1 → XP_021336154.1  actin-binding LIM protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QF47
      Conserved Domains (6) summary
      smart00153
      Location:734 → 769
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 733
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    13. XM_021480481.1 → XP_021336156.1  actin-binding LIM protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M9QJG3
      Conserved Domains (6) summary
      smart00153
      Location:717 → 752
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 716
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    14. XM_021480480.1 → XP_021336155.1  actin-binding LIM protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9QN76
      Conserved Domains (6) summary
      smart00153
      Location:719 → 754
      VHP; Villin headpiece domain
      cd09327
      Location:94 → 145
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:150 → 205
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:231 → 282
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:290 → 345
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:370 → 718
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    15. XM_017358667.2 → XP_017214156.1  actin-binding LIM protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8M6Z923
    Nucleotide Protein
    Heading Accession and Version

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