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    dab2ipa DAB2 interacting protein a [ Danio rerio (zebrafish) ]

    Gene ID: 100002454, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dab2ipaprovided by ZNC
    Official Full Name
    DAB2 interacting protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-516
    See related
    Ensembl:ENSDARG00000069484 AllianceGenome:ZFIN:ZDB-GENE-081104-516
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-83f4.1
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within several processes, including negative regulation of angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway; and reelin-mediated signaling pathway. Orthologous to human DAB2IP (DAB2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (12132581..12338738, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (12095715..12301023, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene netrin g2a Neighboring gene endonuclease G Neighboring gene PHD finger protein 19 Neighboring gene TNF receptor-associated factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Gui H, et al. Genome Biol, 2017 Mar 8. PMID 28274275, Free PMC Article
    2. Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish. Zou J, et al. Circ Res, 2011 Jan 21. PMID 21148433
    3. Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish. Zhong Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29447387, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disabled homolog 2-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      12132581..12338738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303797.3 → XP_009302072.1  disabled homolog 2-interacting protein isoform X2

      UniProtKB/TrEMBL
      A0A8M3AUY3
      Conserved Domains (6) summary
      cd04013
      Location:265 → 404
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:395 → 718
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:391 → 719
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:708 → 1216
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1111 → 1226
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:142 → 323
      PH-like; Pleckstrin homology-like domain

    2. XM_017357419.2 → XP_017212908.1  disabled homolog 2-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8M6YZX5

    3. XM_009303798.3 → XP_009302073.1  disabled homolog 2-interacting protein isoform X3

      UniProtKB/TrEMBL
      A0A8M3B4Q7
      Related
      ENSDARP00000115386.1, ENSDART00000135812.2
      Conserved Domains (6) summary
      cd04013
      Location:172 → 311
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:302 → 625
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:298 → 626
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:615 → 1123
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1018 → 1133
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:48 → 230
      PH-like; Pleckstrin homology-like domain

    4. XM_021478374.1 → XP_021334049.1  disabled homolog 2-interacting protein isoform X4

      UniProtKB/TrEMBL
      A0A8M3B1U1
      Conserved Domains (4) summary
      cd04013
      Location:79 → 218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209 → 532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:522 → 1030
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1 → 137
      PH-like; Pleckstrin homology-like domain

    5. XM_005166905.4 → XP_005166962.1  disabled homolog 2-interacting protein isoform X4

      See identical proteins and their annotated locations for XP_005166962.1

      UniProtKB/TrEMBL
      A0A8M3B1U1
      Conserved Domains (4) summary
      cd04013
      Location:79 → 218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209 → 532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:522 → 1030
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1 → 137
      PH-like; Pleckstrin homology-like domain

    6. XM_009303801.3 → XP_009302076.1  disabled homolog 2-interacting protein isoform X4

      See identical proteins and their annotated locations for XP_009302076.1

      UniProtKB/TrEMBL
      A0A8M3B1U1
      Conserved Domains (4) summary
      cd04013
      Location:79 → 218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209 → 532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:522 → 1030
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1 → 137
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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