iars2 isoleucyl-tRNA synthetase 2, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: iars2provided by ZNC
Official Full Name: isoleucyl-tRNA synthetase 2, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-608
See related: Ensembl:ENSDARG00000044134 AllianceGenome:ZFIN:ZDB-GENE-030616-608
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:zc214p16.3; si:ch211-214p16.3
Summary: Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in mitochondrion. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (25590130..25606911)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (25571742..25587861)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables isoleucine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isoleucine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isoleucyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within isoleucyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: isoleucine--tRNA ligase, mitochondrial

Names: isoleucine tRNA synthetase; isoleucine-tRNA synthetase 2, mitochondrial

NP_001157270.1

EC 6.1.1.5

XP_021322758.1

EC 6.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163798.1 → NP_001157270.1 isoleucine--tRNA ligase, mitochondrial

Status: PROVISIONAL

Source sequence(s)

AL929207, FP015823

UniProtKB/TrEMBL

A0A8M1NS03, F1QUQ0

Related

ENSDARP00000064802.4, ENSDART00000064803.6

Conserved Domains (5) summary

cd07960
Location:680 → 859

Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases

cd00818
Location:441 → 677

IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases

PRK05743
Location:31 → 976

ileS; isoleucyl-tRNA synthetase; Reviewed

pfam13603
Location:330 → 382

tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

cl00015
Location:78 → 214

nt_trans; nucleotidyl transferase superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

25590130..25606911

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467083.1 → XP_021322758.1 isoleucine--tRNA ligase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M9P8Q4

Conserved Domains (1) summary

cl26128
Location:31 → 975

tRNA-synt_1g; tRNA synthetases class I (M)