Format

Send to:

Choose Destination
    • Showing Current items.

    Os9 amplified in osteosarcoma [ Mus musculus (house mouse) ]

    Gene ID: 216440, updated on 5-Aug-2018

    Summary

    Official Symbol
    Os9provided by MGI
    Official Full Name
    amplified in osteosarcomaprovided by MGI
    Primary source
    MGI:MGI:1924301
    See related
    Ensembl:ENSMUSG00000040462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU022351; 4632413K17Rik
    Expression
    Ubiquitous expression in duodenum adult (RPKM 33.8), liver adult (RPKM 33.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Os9 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (127094259..127121160, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (126531315..126558216, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730063M14 gene Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene predicted gene, 40799 Neighboring gene coenzyme Q4 homolog pseudogene Neighboring gene predicted gene, 46185 Neighboring gene predicted gene, 46184

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    protein retention in ER lumen ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Hrd1p ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein OS-9
    Names
    osteosarcoma amplified 9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171026.1NP_001164497.1  protein OS-9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001164497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131760, AK028047, BF470029, CD802565, DV647242
      Consensus CDS
      CCDS48713.1
      UniProtKB/Swiss-Prot
      Q8K2C7
      Related
      ENSMUSP00000128914.1, ENSMUST00000164259.8
      Conserved Domains (2) summary
      pfam07915
      Location:110181
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:175236
      PRKCSH; Glucosidase II beta subunit-like protein
    2. NM_177614.3NP_808282.2  protein OS-9 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is a shorter, compared to isoform 1.
      Source sequence(s)
      AC131760, BF470029, BU703218, BY297242, CD802565, CX566458, DV660362
      Consensus CDS
      CCDS24229.1
      UniProtKB/Swiss-Prot
      Q8K2C7
      Related
      ENSMUSP00000079770.4, ENSMUST00000080975.5
      Conserved Domains (2) summary
      pfam07915
      Location:110181
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:175236
      PRKCSH; Glucosidase II beta subunit-like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      127094259..127121160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243420.1XP_011241722.1  protein OS-9 isoform X1

      Conserved Domains (2) summary
      pfam07915
      Location:677
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:71132
      PRKCSH; Glucosidase II beta subunit-like protein
    Support Center