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    Tor1aip2 torsin A interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 240832, updated on 17-Feb-2018

    Summary

    Official Symbol
    Tor1aip2provided by MGI
    Official Full Name
    torsin A interacting protein 2provided by MGI
    Primary source
    MGI:MGI:3582695
    See related
    Ensembl:ENSMUSG00000050565 Vega:OTTMUSG00000021976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    15kDa; Lull1; C77739; Ifrg15; AA103493; AW060462; AW610675; A130072J07; 1110020D10Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 24.5), large intestine adult (RPKM 11.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tor1aip2 in Genome Data Viewer
    Location:
    1; 1 G3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (156035664..156068861)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (157882794..157915991)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene centrosomal protein 350 Neighboring gene torsin A interacting protein 1 Neighboring gene family with sequence similarity 163, member A Neighboring gene predicted gene, 30472 Neighboring gene tudor domain containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ13142, MGC70203, MGC76434, MGC102429

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    torsin-1A-interacting protein 2; interferon alpha responsive protein
    Names
    15 kDa interferon-responsive protein
    interferon alpha responsive gene, 15 kDa
    interferon alpha responsive protein (15 kDa)
    lumenal domain like LAP1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160180.1NP_001153652.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001153652.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) shares a portion of its 5' UTR, but uses a completely different set of coding exons compared to variant 5. Variant 1 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin A interacting protein 2). Variants 1-4 encode the same protein (isoform a).
      Source sequence(s)
      AK032697, AK150303, BY254976
      Consensus CDS
      CCDS15388.1
      UniProtKB/Swiss-Prot
      Q9ER81
      Related
      ENSMUSP00000107383.2, OTTMUSP00000061313, ENSMUST00000111754.8, OTTMUST00000110039
    2. NM_001160181.1NP_001153653.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001153653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) shares a portion of its 5' UTR, but uses a completely different set of coding exons compared to variant 5. Variant 3 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin A interacting protein 2). Variants 1-4 encode the same protein (isoform a).
      Source sequence(s)
      AK032697, AK150303, BY029314
      Consensus CDS
      CCDS15388.1
      UniProtKB/Swiss-Prot
      Q9ER81
      Related
      ENSMUSP00000095133.2, OTTMUSP00000024678, ENSMUST00000097526.2, OTTMUST00000052164
    3. NM_001160182.1NP_001153654.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001153654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) shares a portion of its 5' UTR, but uses a completely different set of coding exons compared to variant 5. Variant 4 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin A interacting protein 2). Variants 1-4 encode the same protein (isoform a).
      Source sequence(s)
      AA030492, AK032697, AK150303, BU614106
      Consensus CDS
      CCDS15388.1
      UniProtKB/Swiss-Prot
      Q9ER81
      Related
      ENSMUSP00000135107.1, OTTMUSP00000061314, ENSMUST00000128941.7, OTTMUST00000052165
    4. NM_001358626.1NP_001345555.1  torsin-1A-interacting protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159964
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    5. NM_001358627.1NP_001345556.1  torsin-1A-interacting protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159964
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    6. NM_022329.4NP_071724.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_071724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) shares a portion of its 5' UTR, but uses a completely different set of coding exons compared to variant 5. Variant 2 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin A interacting protein 2). Variants 1-4 encode the same protein (isoform a).
      Source sequence(s)
      AK032697, AK150303, BY029314
      Consensus CDS
      CCDS15388.1
      UniProtKB/Swiss-Prot
      Q9ER81
      Related
      ENSMUSP00000067353.8, OTTMUSP00000024677, ENSMUST00000065648.14, OTTMUST00000052163
    7. NM_172843.4NP_766431.3  torsin-1A-interacting protein 2 isoform b

      See identical proteins and their annotated locations for NP_766431.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longer isoform b (torsin-1A-interacting protein 2), compared to isoform a. Variants 5, 6, and 7 encode the same isoform (b).
      Source sequence(s)
      AC159964, AK038024
      Consensus CDS
      CCDS15389.1
      UniProtKB/Swiss-Prot
      Q8BYU6
      Related
      ENSMUSP00000107387.3, OTTMUSP00000024686, ENSMUST00000111757.9, OTTMUST00000052178
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      156035664..156068861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529589.3XP_006529652.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006529652.1

      UniProtKB/Swiss-Prot
      Q8BYU6
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    2. XM_011248003.1XP_011246305.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011246305.1

      UniProtKB/Swiss-Prot
      Q8BYU6
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    3. XM_006529587.3XP_006529650.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006529650.1

      UniProtKB/Swiss-Prot
      Q8BYU6
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    4. XM_006529588.3XP_006529651.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BYU6
      Related
      ENSMUSP00000050817.4, OTTMUSP00000024685, ENSMUST00000060404.4, OTTMUST00000052177
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    5. XM_017320552.1XP_017176041.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BYU6
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    6. XM_017320551.1XP_017176040.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BYU6
      Conserved Domains (1) summary
      pfam05609
      Location:28500
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
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