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    Dtx4 deltex 4, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 207521, updated on 2-Oct-2018

    Summary

    Official Symbol
    Dtx4provided by MGI
    Official Full Name
    deltex 4, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:2672905
    See related
    Ensembl:ENSMUSG00000039982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNF155; AI449438; BC044798; D930042H13
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.0), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dtx4 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (12466329..12502201, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (12540826..12576486, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene pore forming protein-like Neighboring gene macrophage expressed gene 1 Neighboring gene predicted gene, 31208 Neighboring gene family with sequence similarity 111, member A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase DTX4
    Names
    RING-type E3 ubiquitin transferase DTX4
    deltex 4 homolog
    deltex4
    protein deltex-4
    NP_766030.3
    XP_006526879.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172442.3NP_766030.3  E3 ubiquitin-protein ligase DTX4

      See identical proteins and their annotated locations for NP_766030.3

      Status: VALIDATED

      Source sequence(s)
      BC058647, BU705490, CA328050, CF537541, CN525673
      Consensus CDS
      CCDS29631.1
      UniProtKB/Swiss-Prot
      Q6PDK8
      Related
      ENSMUSP00000040229.7, ENSMUST00000045521.7
      Conserved Domains (4) summary
      smart00678
      Location:886
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:473605
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:405466
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02825
      Location:90144
      WWE; WWE domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      12466329..12502201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526816.2XP_006526879.1  E3 ubiquitin-protein ligase DTX4 isoform X1

      Conserved Domains (3) summary
      cd09633
      Location:367499
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:299360
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02825
      Location:138
      WWE; WWE domain
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