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    Dph3 diphthamine biosynthesis 3 [ Mus musculus (house mouse) ]

    Gene ID: 105638, updated on 23-May-2018

    Summary

    Official Symbol
    Dph3provided by MGI
    Official Full Name
    diphthamine biosynthesis 3provided by MGI
    Primary source
    MGI:MGI:1922658
    See related
    Ensembl:ENSMUSG00000021905 Vega:OTTMUSG00000019770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Desr1; KTI11; Zcsl2; DELGIP1; DelgipP1
    Expression
    Ubiquitous expression in testis adult (RPKM 10.1), cerebellum adult (RPKM 7.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dph3 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (32080517..32085692, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32893748..32898851, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41125 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 15 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene predicted gene, 41127 Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • 2610018L09Rik, 5730511P15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-diphthamide biosynthetic process from peptidyl-histidine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of binding ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DPH3 homolog
    Names
    CSL-type zinc finger-containing protein 2
    DPH3 homolog (KTI11, S. cerevisiae)
    delGEF-interacting protein 1
    zinc finger, CSL domain containing 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047433.2NP_001040898.1  DPH3 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC154846, AK048097, DN175457
      Consensus CDS
      CCDS36860.1
      UniProtKB/Swiss-Prot
      Q8K0W9
      UniProtKB/TrEMBL
      D3YXV3
      Related
      ENSMUSP00000120583.1, OTTMUSP00000021343, ENSMUST00000124303.8, OTTMUST00000047288
      Conserved Domains (1) summary
      pfam05207
      Location:645
      zf-CSL; CSL zinc finger
    2. NM_001284346.1NP_001271275.1  DPH3 homolog isoform 1

      See identical proteins and their annotated locations for NP_001271275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC154846, AK048097, DN175457
      Consensus CDS
      CCDS36861.1
      UniProtKB/Swiss-Prot
      Q8K0W9
      Related
      ENSMUSP00000022461.4, OTTMUSP00000021341, ENSMUST00000022461.10, OTTMUST00000047285
      Conserved Domains (1) summary
      pfam05207
      Location:660
      zf-CSL; CSL zinc finger
    3. NM_172254.4NP_758458.1  DPH3 homolog isoform 1

      See identical proteins and their annotated locations for NP_758458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC154846, AK048097, DN175457
      Consensus CDS
      CCDS36861.1
      UniProtKB/Swiss-Prot
      Q8K0W9
      Related
      ENSMUSP00000068491.5, OTTMUSP00000021340, ENSMUST00000067955.11, OTTMUST00000047284
      Conserved Domains (1) summary
      pfam05207
      Location:660
      zf-CSL; CSL zinc finger

    RNA

    1. NR_104303.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC154846, AK048097, DN175457
    2. NR_104304.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154846, AK017764, AK048097, DN175457
      Related
      ENSMUST00000112001.8, OTTMUST00000047286
    3. NR_104305.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC154846, AK048097, BG082470, BY257422

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      32080517..32085692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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