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    Farp2 FERM, RhoGEF and pleckstrin domain protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 227377, updated on 31-Jan-2019

    Summary

    Official Symbol
    Farp2provided by MGI
    Official Full Name
    FERM, RhoGEF and pleckstrin domain protein 2provided by MGI
    Primary source
    MGI:MGI:2385126
    See related
    Ensembl:ENSMUSG00000034066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fir; AI465173; BC009153; mKIAA0793; D030026M03Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 5.0), colon adult (RPKM 4.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Farp2 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (93512104..93621976)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (95408681..95518553)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene septin 2 Neighboring gene predicted gene, 41920 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene Neighboring gene serine/threonine kinase 25 (yeast) Neighboring gene BCL2-related ovarian killer Neighboring gene THAP domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem (from REACTOME)
      SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0793

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rac guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair cycle process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    FERM, ARHGEF and pleckstrin domain-containing protein 2
    Names
    FERM domain including RhoGEF
    FERM, RhoGEF and pleckstrin domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145519.2NP_663494.2  FERM, ARHGEF and pleckstrin domain-containing protein 2

      See identical proteins and their annotated locations for NP_663494.2

      Status: VALIDATED

      Source sequence(s)
      AK050860, AK173028, AW912106, BB663505, BI739824, BP770314, BY130680
      Consensus CDS
      CCDS15191.1
      UniProtKB/Swiss-Prot
      Q91VS8
      Related
      ENSMUSP00000112725.1, ENSMUST00000120301.7
      Conserved Domains (9) summary
      smart00295
      Location:45234
      B41; Band 4.1 homologues
      cd00160
      Location:540723
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:752859
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:9291026
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:9341027
      PH; PH domain
      pfam00373
      Location:131234
      FERM_M; FERM central domain
      pfam08736
      Location:333375
      FA; FERM adjacent (FA)
      pfam09379
      Location:48111
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      93512104..93621976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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