Format

Send to:

Choose Destination
    • Showing Current items.

    Ube2d1 ubiquitin-conjugating enzyme E2D 1 [ Mus musculus (house mouse) ]

    Gene ID: 216080, updated on 5-Aug-2018

    Summary

    Official Symbol
    Ube2d1provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2D 1provided by MGI
    Primary source
    MGI:MGI:2384911
    See related
    Ensembl:ENSMUSG00000019927 Vega:OTTMUSG00000031044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBCH5
    Expression
    Broad expression in CNS E18 (RPKM 61.3), whole brain E14.5 (RPKM 59.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See Ube2d1 in Genome Data Viewer
    Location:
    10; 10 B5.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (71254980..71285262, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (70717728..70748010, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700113B09 gene Neighboring gene transcription factor A, mitochondrial Neighboring gene predicted gene, 34376 Neighboring gene predicted gene 20609

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28550

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    positive regulation of protein polyubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 D1
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme D1
    E2 ubiquitin-conjugating enzyme D1
    E2(17)KB 1
    ubiquitin carrier protein D1
    ubiquitin-conjugating enzyme E2(17)KB 1
    ubiquitin-conjugating enzyme E2-17 kDa 1
    ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog
    ubiquitin-protein ligase D1
    NP_663395.1
    XP_006513541.1
    XP_006513542.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145420.2NP_663395.1  ubiquitin-conjugating enzyme E2 D1

      See identical proteins and their annotated locations for NP_663395.1

      Status: VALIDATED

      Source sequence(s)
      AI836420, AK148364, BY111155
      Consensus CDS
      CCDS35933.1
      UniProtKB/Swiss-Prot
      P61080
      UniProtKB/TrEMBL
      Q3UFQ4
      Related
      ENSMUSP00000020085.6, OTTMUSP00000040551, ENSMUST00000020085.6, OTTMUST00000076911
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      71254980..71285262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513479.2XP_006513542.1  ubiquitin-conjugating enzyme E2 D1 isoform X2

      Conserved Domains (2) summary
      COG5078
      Location:19134
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:19133
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_006513478.2XP_006513541.1  ubiquitin-conjugating enzyme E2 D1 isoform X1

      Conserved Domains (2) summary
      COG5078
      Location:19160
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:19159
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Support Center