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    Appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 216190, updated on 9-Sep-2018

    Summary

    Official Symbol
    Appl2provided by MGI
    Official Full Name
    adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2provided by MGI
    Primary source
    MGI:MGI:2384914
    See related
    Ensembl:ENSMUSG00000020263 Vega:OTTMUSG00000027828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dip3b; Dip3 beta; DIP13 beta
    Expression
    Broad expression in cerebellum adult (RPKM 26.5), adrenal adult (RPKM 22.2) and 26 other tissues See more
    Orthologs

    Genomic context

    See Appl2 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (83600033..83648860, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (83062778..83111409, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family, member L2 Neighboring gene WASH complex subunit 4 Neighboring gene RIKEN cDNA 1500009L16 gene Neighboring gene predicted gene, 33919

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with NuRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DCC-interacting protein 13-beta
    Names
    adapter protein containing PH domain, PTB domain and leucine zipper motif 2
    dip13-beta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145220.2NP_660255.1  DCC-interacting protein 13-beta

      See identical proteins and their annotated locations for NP_660255.1

      Status: VALIDATED

      Source sequence(s)
      AY113706
      Consensus CDS
      CCDS24078.1
      UniProtKB/Swiss-Prot
      Q8K3G9
      UniProtKB/TrEMBL
      Q3TVI6
      Related
      ENSMUSP00000020500.7, OTTMUSP00000034914, ENSMUST00000020500.13, OTTMUST00000068884
      Conserved Domains (4) summary
      cd07632
      Location:20234
      BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
      cd13158
      Location:480613
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:278378
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      83600033..83648860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513511.3XP_006513574.1  DCC-interacting protein 13-beta isoform X5

      Conserved Domains (4) summary
      cd13158
      Location:370503
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:142266
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:168268
      PH; PH domain
      cl12013
      Location:1124
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006513509.3XP_006513572.1  DCC-interacting protein 13-beta isoform X2

      Conserved Domains (4) summary
      cd07632
      Location:20234
      BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
      cd13158
      Location:480613
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:278378
      PH; PH domain
    3. XM_011243404.1XP_011241706.1  DCC-interacting protein 13-beta isoform X3

      See identical proteins and their annotated locations for XP_011241706.1

      Conserved Domains (4) summary
      cd13158
      Location:427560
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:199323
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:225325
      PH; PH domain
      cl12013
      Location:1181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_006513510.2XP_006513573.1  DCC-interacting protein 13-beta isoform X3

      See identical proteins and their annotated locations for XP_006513573.1

      Conserved Domains (4) summary
      cd13158
      Location:427560
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:199323
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:225325
      PH; PH domain
      cl12013
      Location:1181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_006513508.3XP_006513571.1  DCC-interacting protein 13-beta isoform X1

      Conserved Domains (4) summary
      cd13158
      Location:455588
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:227351
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:253353
      PH; PH domain
      cl12013
      Location:27209
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_017313895.1XP_017169384.1  DCC-interacting protein 13-beta isoform X4

    RNA

    1. XR_380384.3 RNA Sequence

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