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    Acaa1a acetyl-Coenzyme A acyltransferase 1A [ Mus musculus (house mouse) ]

    Gene ID: 113868, updated on 9-Sep-2018

    Summary

    Official Symbol
    Acaa1aprovided by MGI
    Official Full Name
    acetyl-Coenzyme A acyltransferase 1Aprovided by MGI
    Primary source
    MGI:MGI:2148491
    See related
    Ensembl:ENSMUSG00000036138 Vega:OTTMUSG00000042191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTL; Acaa; Acaa1; D9Ertd25e
    Expression
    Ubiquitous expression in duodenum adult (RPKM 294.0), liver adult (RPKM 221.7) and 26 other tissues See more

    Genomic context

    See Acaa1a in Genome Data Viewer
    Location:
    9 F3; 9 71.33 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (119341052..119350296)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (119250412..119259413)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene oxidative-stress responsive 1 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene activin receptor IIB

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7090

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acetate CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acetyl-CoA C-acetyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    acetyl-CoA C-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    palmitoyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    3-ketoacyl-CoA thiolase A, peroxisomal
    Names
    acetyl-CoA acyltransferase A
    beta-ketothiolase A
    peroxisomal 3-ketoacyl-CoA thiolase
    peroxisomal 3-oxoacyl-CoA thiolase A
    peroxisomal 3-oxoacyl-Coenzyme A thiolase
    thiolase A
    NP_570934.1
    XP_006511986.1
    XP_006511987.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357516.1NP_001344445.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC128702
      Conserved Domains (1) summary
      cl27751
      Location:1268
      Thiolase_N; Thiolase, N-terminal domain
    2. NM_130864.3NP_570934.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 precursor

      See identical proteins and their annotated locations for NP_570934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC128702
      Consensus CDS
      CCDS23613.1
      UniProtKB/Swiss-Prot
      Q921H8
      Related
      ENSMUSP00000042351.5, OTTMUSP00000061838, ENSMUST00000039784.11, OTTMUST00000110753
      Conserved Domains (2) summary
      PLN02287
      Location:1420
      PLN02287; 3-ketoacyl-CoA thiolase
      cd00751
      Location:39421
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      119341052..119350296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511923.1XP_006511986.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

      See identical proteins and their annotated locations for XP_006511986.1

      UniProtKB/Swiss-Prot
      Q921H8
      Conserved Domains (2) summary
      PLN02287
      Location:1420
      PLN02287; 3-ketoacyl-CoA thiolase
      cd00751
      Location:39421
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    2. XM_006511924.3XP_006511987.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X2

      Conserved Domains (1) summary
      cl27751
      Location:1268
      Thiolase_N; Thiolase, N-terminal domain
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