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    Inava innate immunity activator [ Mus musculus (house mouse) ]

    Gene ID: 67313, updated on 29-May-2018

    Summary

    Official Symbol
    Inavaprovided by MGI
    Official Full Name
    innate immunity activatorprovided by MGI
    Primary source
    MGI:MGI:1921579
    See related
    Ensembl:ENSMUSG00000041605 Vega:OTTMUSG00000029725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Mgi54; AI586180; 1700034M08Rik; 4933426C09Rik; 5730559C18Rik
    Expression
    Biased expression in colon adult (RPKM 37.5), stomach adult (RPKM 18.3) and 11 other tissues See more
    Orthologs

    Genomic context

    See Inava in Genome Data Viewer
    Location:
    1 E4; 1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (136213522..136234293, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (138110108..138130841, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 21B Neighboring gene maestro heat-like repeat family member 3 Neighboring gene predicted gene 3878 Neighboring gene G protein-coupled receptor 25 Neighboring gene calmodulin regulated spectrin-associated protein family, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10901

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptidoglycan ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    innate immunity activator protein; uncharacterized protein C1orf106 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028872.3NP_083148.3  innate immunity activator protein

      See identical proteins and their annotated locations for NP_083148.3

      Status: VALIDATED

      Source sequence(s)
      BB611110, BC052416, BY388978
      Consensus CDS
      CCDS15325.2
      UniProtKB/Swiss-Prot
      Q7TN12
      UniProtKB/TrEMBL
      G3X9Z8
      Related
      ENSMUSP00000113785.1, OTTMUSP00000038222, ENSMUST00000120339.7, OTTMUST00000073752
      Conserved Domains (1) summary
      pfam11819
      Location:107230
      DUF3338; Domain of unknown function (DUF3338)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      136213522..136234293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529802.3XP_006529865.1  uncharacterized protein C1orf106 homolog isoform X1

      Conserved Domains (1) summary
      pfam11819
      Location:107230
      DUF3338; Domain of unknown function (DUF3338)
    2. XM_006529803.3XP_006529866.1  uncharacterized protein C1orf106 homolog isoform X2

      Conserved Domains (1) summary
      pfam11819
      Location:74197
      DUF3338; Domain of unknown function (DUF3338)
    3. XM_006529806.3XP_006529869.1  uncharacterized protein C1orf106 homolog isoform X3

      See identical proteins and their annotated locations for XP_006529869.1

      Conserved Domains (1) summary
      pfam11819
      Location:8131
      DUF3338; Domain of unknown function (DUF3338)
    4. XM_006529804.3XP_006529867.1  uncharacterized protein C1orf106 homolog isoform X3

      See identical proteins and their annotated locations for XP_006529867.1

      Conserved Domains (1) summary
      pfam11819
      Location:8131
      DUF3338; Domain of unknown function (DUF3338)
    5. XM_006529805.3XP_006529868.1  uncharacterized protein C1orf106 homolog isoform X3

      See identical proteins and their annotated locations for XP_006529868.1

      Conserved Domains (1) summary
      pfam11819
      Location:8131
      DUF3338; Domain of unknown function (DUF3338)
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