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    Eif4e2 eukaryotic translation initiation factor 4E member 2 [ Mus musculus (house mouse) ]

    Gene ID: 26987, updated on 27-Jan-2018

    Summary

    Official Symbol
    Eif4e2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E member 2provided by MGI
    Primary source
    MGI:MGI:1914440
    See related
    Ensembl:ENSMUSG00000026254 Vega:OTTMUSG00000021766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4el3; AI036339; AV129531; D0H0S6743E; 2700069E09Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 12.5), placenta adult (RPKM 6.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif4e2 in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (87213901..87240488)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89110489..89137063)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene cholinergic receptor, nicotinic, gamma polypeptide Neighboring gene EF hand domain containing 1 Neighboring gene predicted gene, 41911 Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 13

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Dysregulated miRNA Targeting in Insulin/PI3K-AKT Signaling, organism-specific biosystem (from WikiPathways)
      Dysregulated miRNA Targeting in Insulin/PI3K-AKT Signaling, organism-specific biosystemThis pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 di...
    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
      PI3K/Akt/mTOR signaling pathway
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • eIF4F complex, organism-specific biosystem (from KEGG)
      eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • eIF4F complex, conserved biosystem (from KEGG)
      eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E type 2
    Names
    eIF-4E type 2
    eIF4E type 2
    eIF4E-2
    eIF4E-like protein 4E-LP
    eukaryotic translation initiation factor 4E like 3
    mRNA cap-binding protein type 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039169.1NP_001034258.1  eukaryotic translation initiation factor 4E type 2 isoform 2

      See identical proteins and their annotated locations for NP_001034258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC102611, AK017221
      Consensus CDS
      CCDS15131.1
      UniProtKB/TrEMBL
      Q0P688
      Related
      ENSMUSP00000108857.3, OTTMUSP00000024358, ENSMUST00000113231.3, OTTMUST00000051664
      Conserved Domains (1) summary
      pfam01652
      Location:50208
      IF4E; Eukaryotic initiation factor 4E
    2. NM_001039170.1NP_001034259.1  eukaryotic translation initiation factor 4E type 2 isoform 1

      See identical proteins and their annotated locations for NP_001034259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC102611, AK032965
      Consensus CDS
      CCDS35652.1
      UniProtKB/Swiss-Prot
      Q8BMB3
      Related
      ENSMUSP00000108859.1, OTTMUSP00000024354, ENSMUST00000113233.7, OTTMUST00000051660
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E
    3. NM_001347083.1NP_001334012.1  eukaryotic translation initiation factor 4E type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102611
      Consensus CDS
      CCDS83571.1
      UniProtKB/TrEMBL
      D3Z729
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E
    4. NM_023314.3NP_075803.2  eukaryotic translation initiation factor 4E type 2 isoform 3

      See identical proteins and their annotated locations for NP_075803.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3'-most exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102611, AK032965, AK076067
      Consensus CDS
      CCDS15130.1
      UniProtKB/Swiss-Prot
      Q8BMB3
      UniProtKB/TrEMBL
      G3X9H1
      Related
      ENSMUSP00000075699.5, OTTMUSP00000024353, ENSMUST00000076362.11, OTTMUST00000051659
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      87213901..87240488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529674.3XP_006529737.1  eukaryotic translation initiation factor 4E type 2 isoform X4

      UniProtKB/TrEMBL
      D3YUV9
      Related
      ENSMUSP00000053403.7, OTTMUSP00000024355, ENSMUST00000050876.13, OTTMUST00000051661
      Conserved Domains (1) summary
      pfam01652
      Location:58214
      IF4E; Eukaryotic initiation factor 4E
    2. XM_006529671.3XP_006529734.1  eukaryotic translation initiation factor 4E type 2 isoform X2

      Related
      ENSMUSP00000108861.1, OTTMUSP00000024359, ENSMUST00000113235.7, OTTMUST00000051665
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E
    3. XM_006529670.3XP_006529733.1  eukaryotic translation initiation factor 4E type 2 isoform X2

      See identical proteins and their annotated locations for XP_006529733.1

      UniProtKB/TrEMBL
      D3Z729
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E
    4. XM_006529669.1XP_006529732.1  eukaryotic translation initiation factor 4E type 2 isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:53209
      IF4E; Eukaryotic initiation factor 4E
    5. XM_006529673.1XP_006529736.1  eukaryotic translation initiation factor 4E type 2 isoform X3

      Conserved Domains (1) summary
      pfam01652
      Location:58214
      IF4E; Eukaryotic initiation factor 4E
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