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    Itm2c integral membrane protein 2C [ Mus musculus (house mouse) ]

    Gene ID: 64294, updated on 5-Aug-2018

    Summary

    Official Symbol
    Itm2cprovided by MGI
    Official Full Name
    integral membrane protein 2Cprovided by MGI
    Primary source
    MGI:MGI:1927594
    See related
    Ensembl:ENSMUSG00000026223 Vega:OTTMUSG00000029979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E25; BRI3; E25C; ITM3; Bricd2c; 3110038L02Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 251.4), cortex adult (RPKM 160.0) and 26 other tissues See more
    Orthologs

    Genomic context

    See Itm2c in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (85894286..85908698)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (87791085..87805273)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9930111H07 gene Neighboring gene calcium binding protein 39 Neighboring gene predicted gene, 32302 Neighboring gene RIKEN cDNA 4933407L21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of amyloid precursor protein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integral membrane protein 2C
    Names
    integral membrane protein 3
    transmembrane protein BRI3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022417.3NP_071862.2  integral membrane protein 2C

      See identical proteins and their annotated locations for NP_071862.2

      Status: VALIDATED

      Source sequence(s)
      AK036377, BE991371, BY255015
      Consensus CDS
      CCDS35641.1
      UniProtKB/Swiss-Prot
      Q91VK4
      Related
      ENSMUSP00000027425.9, OTTMUSP00000038673, ENSMUST00000027425.15, OTTMUST00000074348
      Conserved Domains (1) summary
      smart01039
      Location:138230
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      85894286..85908698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321919.1XP_017177408.1  integral membrane protein 2C isoform X1

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