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    Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 26908, updated on 9-Sep-2018

    Summary

    Official Symbol
    Eif2s3yprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linkedprovided by MGI
    Primary source
    MGI:MGI:1349430
    See related
    Ensembl:ENSMUSG00000069049 Vega:OTTMUSG00000021559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spy; Tfy; Eif-2gy
    Expression
    Broad expression in CNS E18 (RPKM 11.4), CNS E14 (RPKM 7.7) and 17 other tissues See more

    Genomic context

    See Eif2s3y in Genome Data Viewer
    Location:
    Y; Y A1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) Y NC_000087.7 (1010578..1046811)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) Y NC_000087.6 (347055..365037)

    Chromosome Y - NC_000087.7Genomic Context describing neighboring genes Neighboring gene ras homolog A translocated to the Y, pseudogene 3 Neighboring gene lysine (K)-specific demethylase 5D Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome Neighboring gene predicted gene, 39552

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystem
      Translation Factors

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2 subunit 3, Y-linked
    Names
    eIF-2-gamma Y
    eukaryotic translation initiation factor 2 subunit gamma, Y-linked
    spermatogenesis Y
    spermatogonial proliferation factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357094.1NP_001344023.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC145392
      Conserved Domains (1) summary
      cl27768
      Location:1287
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
    2. NM_012011.2NP_036141.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 1

      See identical proteins and their annotated locations for NP_036141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC145392, AI661184, AK009448, BY711372
      Consensus CDS
      CCDS30542.1
      UniProtKB/Swiss-Prot
      Q9Z0N2
      Related
      ENSMUSP00000088736.3, OTTMUSP00000024027, ENSMUST00000091197.3
      Conserved Domains (4) summary
      cd01888
      Location:42248
      eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
      PTZ00327
      Location:13466
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
      cd03688
      Location:249362
      eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
      cd15490
      Location:365459
      eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000087.7 Reference GRCm38.p4 C57BL/6J

      Range
      1010578..1046811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248593.1XP_011246895.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

      See identical proteins and their annotated locations for XP_011246895.1

      Conserved Domains (4) summary
      cd01888
      Location:42248
      eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
      PTZ00327
      Location:13452
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
      cd03688
      Location:249362
      eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
      cd15490
      Location:365452
      eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma
    2. XM_006531608.3XP_006531671.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

      See identical proteins and their annotated locations for XP_006531671.1

      Conserved Domains (4) summary
      cd01888
      Location:42248
      eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
      PTZ00327
      Location:13452
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
      cd03688
      Location:249362
      eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
      cd15490
      Location:365452
      eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma
    3. XM_006531609.1XP_006531672.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X2

      Conserved Domains (1) summary
      cl27768
      Location:1287
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
    4. XM_006531610.3XP_006531673.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X2

      See identical proteins and their annotated locations for XP_006531673.1

      Conserved Domains (1) summary
      cl27768
      Location:1287
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_879402.2 RNA Sequence

    2. XR_001782883.1 RNA Sequence

    3. XR_001782884.1 RNA Sequence

    4. XR_001782887.1 RNA Sequence

    5. XR_001782885.1 RNA Sequence

    6. XR_001782886.1 RNA Sequence

    7. XR_388245.1 RNA Sequence

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