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    Mettl1 methyltransferase like 1 [ Mus musculus (house mouse) ]

    Gene ID: 17299, updated on 12-Aug-2018

    Summary

    Official Symbol
    Mettl1provided by MGI
    Official Full Name
    methyltransferase like 1provided by MGI
    Primary source
    MGI:MGI:1339986
    See related
    Ensembl:ENSMUSG00000006732 Vega:OTTMUSG00000030570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810012D02Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.7), placenta adult (RPKM 9.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mettl1 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (127041643..127046365)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (126478988..126482517)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane-associated ring finger (C3HC4) 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tRNA (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to tRNA (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tRNA (guanine-N(7)-)-methyltransferase
    NP_034922.1
    XP_006513375.1
    XP_006513376.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010792.1NP_034922.1  tRNA (guanine-N(7)-)-methyltransferase

      See identical proteins and their annotated locations for NP_034922.1

      Status: PROVISIONAL

      Source sequence(s)
      AB023619
      Consensus CDS
      CCDS24223.1
      UniProtKB/Swiss-Prot
      Q9Z120
      Related
      ENSMUSP00000006915.7, OTTMUSP00000039739, ENSMUST00000006915.13, OTTMUST00000075701
      Conserved Domains (2) summary
      COG0220
      Location:10246
      TrmB; tRNA G46 methylase TrmB [Translation, ribosomal structure and biogenesis]
      pfam02390
      Location:71248
      Methyltransf_4; Putative methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      127041643..127046365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513313.2XP_006513376.1  tRNA (guanine-N(7)-)-methyltransferase isoform X2

      Related
      ENSMUSP00000113030.1, OTTMUSP00000039740, ENSMUST00000120542.7, OTTMUST00000075702
      Conserved Domains (1) summary
      cl17173
      Location:118232
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006513312.2XP_006513375.1  tRNA (guanine-N(7)-)-methyltransferase isoform X1

      Conserved Domains (2) summary
      COG0220
      Location:57293
      TrmB; tRNA G46 methylase TrmB [Translation, ribosomal structure and biogenesis]
      pfam02390
      Location:118295
      Methyltransf_4; Putative methyltransferase
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