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    Lamc1 laminin, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 226519, updated on 9-Sep-2018

    Summary

    Official Symbol
    Lamc1provided by MGI
    Official Full Name
    laminin, gamma 1provided by MGI
    Primary source
    MGI:MGI:99914
    See related
    Ensembl:ENSMUSG00000026478 Vega:OTTMUSG00000030992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lamb2
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 50.7), bladder adult (RPKM 46.9) and 27 other tissues See more
    Orthologs

    Genomic context

    See Lamc1 in Genome Data Viewer
    Location:
    1 G3; 1 65.3 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (153218922..153332786, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (155066052..155179916, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene laminin, gamma 2 Neighboring gene predicted pseudogene 8818 Neighboring gene Riken cDNA E330020D12 gene Neighboring gene predicted gene, 46246

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    extracellular matrix structural constituent ISO
    Inferred from Sequence Orthology
    more info
     
    glycosphingolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    hemidesmosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    laminin-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    laminin-10 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic cleft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit gamma-1
    Names
    S-LAM gamma
    S-laminin subunit gamma
    laminin B2 chain
    laminin-1 subunit gamma
    laminin-10 subunit gamma
    laminin-11 subunit gamma
    laminin-2 subunit gamma
    laminin-3 subunit gamma
    laminin-4 subunit gamma
    laminin-6 subunit gamma
    laminin-7 subunit gamma
    laminin-8 subunit gamma
    laminin-9 subunit gamma

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010683.2NP_034813.2  laminin subunit gamma-1 precursor

      See identical proteins and their annotated locations for NP_034813.2

      Status: VALIDATED

      Source sequence(s)
      AC117550, AC159966
      Consensus CDS
      CCDS15370.1
      UniProtKB/TrEMBL
      F8VQJ3
      Related
      ENSMUSP00000027752.8, OTTMUSP00000040460, ENSMUST00000027752.14, OTTMUST00000076764
      Conserved Domains (11) summary
      cl14654
      Location:11781310
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00136
      Location:42282
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:933978
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:551676
      LamB; Laminin B domain
      smart00283
      Location:10891300
      MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
      cd00055
      Location:9801027
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:443490
      Laminin_EGF; Laminin EGF domain
      pfam05276
      Location:13591585
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
      pfam17002
      Location:11981403
      DUF5089; Domain of unknown function (DUF5089)
      cl02488
      Location:10471252
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl21478
      Location:13911503
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      153218922..153332786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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